Despite advances in the differentiation of insulin-producing cells from human embryonic
stem cells, the generation of mature functional β cells in vitro has remained elusive. To …

Pancreatic β cells differentiate during fetal life, but only postnatally acquire the capacity for
glucose-stimulated insulin secretion (GSIS). How this happens is not clear. In exploring what …

Regulatory T (Treg) cells maintain immune tolerance through the master transcription factor
forkhead box P3 (FOXP3), which is crucial for Treg cell function and homeostasis. We …

The nuclear cap-binding complex (CBC) stimulates processing reactions of capped RNAs,
including their splicing, 3′-end formation, degradation, and transport. CBC effects are …

Next generation sequencing studies have highlighted discrepancies in β-cells which exist
between mice and men. Numerous reports have identified MAF BZIP Transcription Factor B (…

To study disease development, an inventory of an organ's cell types and understanding of
physiologic function is paramount. Here, we performed single-cell RNA-sequencing to …

In the version of this article originally published, the Gene Expression Omnibus (GEO)
accession number listed in the data availability section was incorrectly given as GSE10979 …

… Faisant écho à l’atelier d’Aristide Maillol reconstitué au sein du musée, le mythique
atelier parisien de Giacometti sera également évoqué par un ensemble de lithographies de l’artiste …

… Giacometti was an avid participant in intellectual conversations with his Parisian friends, and
the rapport between him and Sartre resulted in Giacometti's asking him to write an essay for …

Lineage tracing using genetically engineered mouse models is an essential tool for investigating
cell-fate decisions of progenitor cells and biology of mature cell types, with relevance to …