Post-transcriptional gene expression regulation of RNA has emerged as a key factor that
controls mammalian protein production. RNA trafficking, translation efficiency, and stability are …

Epitranscriptomic regulation controls information flow through the central dogma and provides
unique opportunities for manipulating cells at the RNA level. However, both fundamental …

Chemical modifications to messenger RNA are increasingly recognized as a critical regulatory
layer in the flow of genetic information, but quantitative tools to monitor RNA modifications …

Long noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules
that are involved in many aspects of brain function. Emerging evidence indicates that …

The RNA modification N 6 -methyladenosine (m 6 A) regulates the interaction between RNA
and various RNA binding proteins within the nucleus and other subcellular compartments …

All aspects of mRNA lifetime and function, including its stability, translation into protein, and
trafficking through the cell, are tightly regulated through coordinated post-transcriptional …

Background Recent discovery of the gene editing system - CRISPR (Clustered Regularly
Interspersed Short Palindromic Repeats) associated proteins (Cas), has resulted in its …

RNA has long been an enticing therapeutic target, but is now garnering increased attention,
largely driven by clinical successes of RNA interference–based drugs. While gene …

Long noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules
involved in many aspects of brain function. Emerging evidence indicates that lncRNAs are …

RNA base editors should ideally be free of immunogenicity, compact, efficient and specific,
which has not been achieved for C>U editing. Here we first describe a compact C>U editor …