User profiles for Sina Gharib

Sina Gharib

Professor of Medicine, University of Washington
Verified email at uw.edu
Cited by 17063

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

…, T Lehtimäki, DI Boomsma, BM Psaty, SA Gharib… - Nature …, 2021 - nature.com
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…

Systematic identification of trans eQTLs as putative drivers of known disease associations

…, V Salomaa, J Brody, A Suchy-Dicey, SA Gharib… - Nature …, 2013 - nature.com
Identifying the downstream effects of disease-associated SNPs is challenging. To help
overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in …

[HTML][HTML] Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL

…, S Pennathur, PS Green, SA Gharib… - The Journal of …, 2007 - Am Soc Clin Investig
HDL lowers the risk for atherosclerotic cardiovascular disease by promoting cholesterol
efflux from macrophage foam cells. However, other antiatherosclerotic properties of HDL are …

Epigenetic signatures of cigarette smoking

…, BM Psaty, KD Taylor, SA Gharib… - Circulation …, 2016 - Am Heart Assoc
Background— DNA methylation leaves a long-term signature of smoking exposure and is one
potential mechanism by which tobacco exposure predisposes to adverse health outcomes…

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

DB Hancock, M Eijgelsheim, JB Wilk, SA Gharib… - Nature …, 2010 - nature.com
Spirometric measures of lung function are heritable traits that reflect respiratory health and
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …

[HTML][HTML] The transcriptional landscape of age in human peripheral blood

…, HHH Göring, M Fornage, Y Liu, SA Gharib… - Nature …, 2015 - nature.com
Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …

Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

…, T Lehtimäki, D Boomsma, BM Psaty, SA Gharib… - BioRxiv, 2018 - biorxiv.org
While many disease-associated variants have been identified through genome-wide association
studies, their downstream molecular consequences remain unclear. To identify these …

[HTML][HTML] Genetic diversity fuels gene discovery for tobacco and alcohol use

…, BI Freedman, ME Gabrielsen, ME Garrett, SA Gharib… - Nature, 2022 - nature.com
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide
deaths, respectively, due largely to broad increased risk for disease and injury 1 , 2 , 3 – …

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

…, U Gehring, F Geller, J Genuneit, SA Gharib… - Nature …, 2018 - nature.com
We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

MS Artigas, DW Loth, LV Wain, SA Gharib, M Obeidat… - Nature …, 2011 - nature.com
Pulmonary function measures reflect respiratory health and are used in the diagnosis of
chronic obstructive pulmonary disease. We tested genome-wide association with forced …