Bipolar Disorder (BD) has been conceptualized as both a cyclic and a progressive disorder.
Mechanisms involved in neuroprogression in BD remain largely unknown although several …

Child maltreatment is associated with an increased risk of psychiatric disorders, and a range
of health problems later in life. Research suggests that adverse events early in life can lead …

Telomeres are repetitive DNA sequences at the ends of chromatids that shorten following
each cell replication. Once telomeres reach a critical length, DNA defense mechanisms can …

Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …

Background: There is robust evidence that schizophrenia is characterized by immune-inflammatory
abnormalities, including variations on cytokine levels. The results of previous studies…

Objective To investigate possible differences in peripheral levels of chemokines, BDNF and
oxidative markers between patients with Schizophrenia (SZ) and matched healthy controls, …

Psychotic disorders are accompanied by activation of the immune inflammatory response
system (IRS). The compensatory immune-regulatory system (CIRS) is a regulatory immune …

Backgroound Schizophrenia is accompanied by increased lipid peroxidation and nitric oxide
(NO) levels and by lowered antioxidant levels. However, the effect of antipsychotic agents …

In schizophrenia, genetic and environmental factors affect neurodevelopment and
neuroprogressive trajectory. Altered expression of neuro-immune genes and increased levels of …

… Mari a b e , Sintia I. Belangero a d e , Rodrigo A. Bressan a b e , Elisa Brietzke a e , Andrea
… Jair de Jesus Mari, Sintia Iole Belangero, Rodrigo A. Bressan and Elisa Brietzke reviewed …