Arginine methylation is a common posttranslational modification (PTM) that alters roughly
0.5% of all arginine residues in the cells. There are three types of arginine methylation: …

The human genome encodes a family of nine protein arginine methyltransferases (PRMT1–9),
whose members can catalyse three distinct types of methylation on arginine residues. …

Stress granules (SGs) are cytoplasmic condensates of stalled messenger ribonucleoprotein
complexes (mRNPs) that form when eukaryotic cells encounter environmental stress. RNA-…

DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant
DNA methylation patterns, including global hypomethylation and regional hypermethylation, …

The coactivator associated arginine methyltransferase (CARM1) promotes transcription, as
its name implies. It does so by modifying histones and chromatin bound proteins. We …

Heat shock factor 1 (HSF1) is well known for its role in the heat shock response (HSR),
where it drives a transcriptional program comprising heat shock protein (HSP) genes, and in …

All cells contain specialized signaling pathways that enable adaptation to specific molecular
stressors. Yet, whether these pathways are centrally regulated in complex physiological …

Tissue inhibitors of metalloproteinases (TIMPs) are multifaceted molecules that exhibit
properties beyond their classical proteinase inhibitory function. Although TIMP-1 is a known …

Protein arginine methyltransferases (PRMTs) catalyze the post-translational monomethylation
(Rme1), asymmetric (Rme2a), or symmetric (Rme2s) dimethylation of arginine. To …

PRMT5 is the primary enzyme responsible for the deposition of the symmetric dimethylarginine
in mammalian cells. In an effort to understand how PRMT5 is regulated, we identified a …