Sperm DNA fragmentation has been associated with reduced fertilization rates, embryo
quality, pregnancy rates and increased miscarriage rates. Various methods exist to test sperm …

BACKGROUND Although chromosomal mosaicism in human preimplantation embryos has
been described for almost two decades, its exact prevalence is still unknown. The …

Cryopreservation of human embryos is now a routine procedure in assisted reproductive
technologies laboratories. There is no consensus on the superiority of any protocol, and …

The male-specific region of the Y chromosome, the MSY, differentiates the sexes and
comprises 95% of the chromosome's length. Here, we report that the MSY is a mosaic of …

Background Pregnancy rates in women of advanced maternal age undergoing in vitro
fertilization (IVF) are disappointingly low. It has been suggested that the use of preimplantation …

It is widely believed that at least three nonoverlapping regions of the human Y chromosome—AZFa,
AZFb, and AZFc ("azoospermia factors"a, b, and c)—are essential for normal …

Many human Y-chromosomal deletions are thought to severely impair reproductive fitness,
which precludes their transmission to the next generation and thus ensures their rarity in the …

The human Y chromosome began to evolve from an autosome hundreds of millions of years
ago, acquiring a sex-determining function and undergoing a series of inversions that …

Context Young boys treated with high-dose chemotherapy are often confronted with infertility
once they reach adulthood. Cryopreserving testicular tissue before chemotherapy and …

Although much structural polymorphism in the human genome has been catalogued 1 , 2 , 3
, 4 , 5 , the kinetics of underlying change remain largely unexplored. Because human Y …