Changes in neuronal activity create local and transient changes in energy demands at
synapses. Here we discover a metabolic compartment that forms in vivo near synapses to meet …

Molecular characterization of cell types using single-cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs. We …

Eleven spontaneous mutations of acetyl‐ C o A carboxylase have been identified in many
herbicide‐resistant populations of 42 species of grassy weeds, hampering application of …

Although much is known about the biochemical regulation of glycolytic enzymes, less is
understood about how they are organized inside cells. We systematically examine the dynamic …

The extent splicing is regulated at single-cell resolution has remained controversial due to
both available data and methods to interpret it. We apply the SpliZ, a new statistical approach, …

Objective Recent observations in systemic juvenile idiopathic arthritis (JIA) suggest an
increasing incidence of high‐mortality interstitial lung disease often characterized by a variant of …

Early stages of deadly respiratory diseases including COVID-19 are challenging to elucidate
in humans. Here, we define cellular tropism and transcriptomic effects of SARS-CoV-2 virus …

Objectives: Recent observations in systemic Juvenile Idiopathic Arthritis (sJIA) suggest an
increasing incidence of high-mortality interstitial lung disease (sJIA-LD) often characterized by …

Early stages of deadly respiratory diseases such as COVID-19 have been challenging to
elucidate due to lack of an experimental system that recapitulates the cellular and structural …

We have studied a series of human acetyl‐CoA carboxylase (ACC) 1 and ACC2 proteins
with deletions and/or Ser to Ala substitutions of the known phosphorylation sites. In vitro …