Sickle human hemoglobin (Hb) confers a survival advantage to individuals living in endemic
areas of malaria, the disease caused by Plasmodium infection. As demonstrated hereby, …

The conserved Hippo tumor suppressor pathway is a key kinase cascade that controls tissue
growth by regulating the nuclear import and activity of the transcription co-activator Yorkie. …

Infection by Plasmodium , the causative agent of malaria, is associated with hemolysis and
therefore with release of hemoglobin from RBC. Under inflammatory conditions, cell-free …

Sepsis is an often lethal syndrome resulting from maladaptive immune and metabolic responses
to infection, compromising host homeostasis. Disease tolerance is a defense strategy …

The tumour microenvironment (TME) shapes disease progression and influences therapeutic
response. Most aggressive solid tumours have high levels of myeloid cell infiltration, …

The clinically silent Plasmodium liver stage is an obligatory step in the establishment of
malaria infection and disease. We report here that expression of heme oxygenase-1 (HO-1, …

3D cell tumour models are generated mainly in non-scalable culture systems, using bioactive
scaffolds. Many of these models fail to reflect the complex tumour microenvironment and …

Disease tolerance is a defense strategy that limits the fitness costs of infection irrespectively
of pathogen burden. While restricting iron (Fe) availability to pathogens is perceived as a …

Currently there is an effort toward the development of in vitro cancer models more predictive
of clinical efficacy. The onset of advanced analytical tools and imaging technologies has …

There is cumulating evidence that in vitro 3D tumor models with increased physiological
relevance can improve the predictive value of pre‐clinical research and ultimately contribute to …