Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression

…, A Benito-Martin, H Ladumor, S Oshchepkova… - The Journal of steroid …, 2019 - Elsevier
Obesity is a risk factor for estrogen receptor-positive (ER+) breast cancer after menopause.
The pro-proliferative effects of estrogens are well characterized and there is a growing body …

Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2

…, M Foronda, LE Dow, S Oshchepkova… - Science translational …, 2023 - science.org
Obesity, defined as a body mass index (BMI) ≥ 30, is an established risk factor for breast
cancer among women in the general population after menopause. Whether elevated BMI is a …

Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

CMC Au, JB Furness, K Britt, S Oshchepkova… - Elife, 2020 - elifesciences.org
Breast cancer is the most common type of cancer in women and notwithstanding important
therapeutic advances, remains the second leading cause of cancer-related death. Despite …

Obesity promotes breast epithelium DNA damage in BRCA mutation carriers

…, O Elemento, M Foronda, LE Dow, S Oshchepkova… - bioRxiv, 2022 - biorxiv.org
Obesity is an established risk factor for breast cancer among women in the general population
after menopause. Whether elevated bodyweight is a risk factor for women with a germline …

[PDF][PDF] The Ray Tracing based Tool for Generation Artificial Images and Neural Network Training.

A Kolker, S Oshchepkova, Z Pershina, L Dimitrov… - KMIS, 2020 - academia.edu
Creating quality-annotated dataset is one of the main tasks in the field of deep learning
technologies for pattern recognition. However, in the real world, collecting a sufficient number of …

[HTML][HTML] understanding the role of adipocytes and the tumor microenvironment on doxorubicin therapy of breast cancer in a tissue engineered, patient specific, high …

…, A Samadi, J Buro, S Oshchepkova… - … Surgery–Global Open, 2019 - journals.lww.com
METHODS: Under an approved IRB, breast tissue was acquired from patients and differentially
processed to isolate mature adipocytes, stromal cells, and breast organoids which were …

SAT-339 Cross-Talk with Breast Adipose Tissue Contributes to Obesity-induced DNA Damage in BRCA Mutant Breast Epithelial Cells

P Bhardwaj, N Iyengar, S Oshchepkova… - Journal of the …, 2019 - academic.oup.com
Background: Obese women who carry a mutation in the DNA repair enzymes BRCA1 and/or
BRCA2 are at a greater risk of developing breast cancer compared with lean BRCA1/2 …

Abstract P2-06-03: Obesity is associated with DNA damage in the breast epithelium of BRCA1 and BRCA2 mutation carriers: A role for estrogens & strategies for …

P Bhardwaj, NM Iyengar, S Oshchepkova, P Piloco… - Cancer Research, 2022 - AACR
Background: Elevated bodyweight is a risk factor for breast cancer development in women
who carry a mutation in the DNA repair enzymes BRCA1 and BRCA2. However, the …

Unacylated ghrelin and AZP531 suppress the 3D growth of breast cancers

CMC Au, JB Furness, K Britt, S Oshchepkova… - bioRxiv, 2020 - biorxiv.org
Breast cancer is the most common type of cancer in women and notwithstanding important
therapeutic advances, it remains the second leading cause of cancer-related death in the US. …

Abstract QS36: A Vascularized, Three-dimensional Biomimetic Platform for Patient-Specific, ex-vivo studies of Breast Cancer Invasion and Metastasis

…, J Buro, A Samadi, S Oshchepkova… - … Surgery–Global Open, 2019 - journals.lww.com
126 QS36 A Vascularized, Three-dimensional Biomimetic Platform for Patient-Specific, ex-vivo
studies of Breast Cancer Invasion a Page 1 126 PRS Global Open • 2019 Outcomes of …