It is currently believed that type I and III interferons (IFNs) have redundant functions. However,
the preferential distribution of type III IFN receptor on epithelial cells suggests functional …

Stress granules (SGs) are formed in the cytosol as an acute response to environmental
cues and activation of the integrated stress response (ISR), a central signaling pathway …

Experimental studies of the innate immune response of mammalian cells to viruses reveal
pervasive heterogeneity at the level of single cells. Interferons are induced only in a fraction of …

Local cell densities and positioning within cellular monolayers and stratified epithelia have
important implications for cell interactions and the functionality of various biological processes…

Isogenic cells respond in a heterogeneous manner to interferon. Using a micropatterning
approach combined with high-content imaging and spatial analyses, we characterized how the …

Adaptation is an important property of living organisms enabling them to cope with environmental
stress and maintaining homeostasis. Adaptation is mediated by signaling pathways …

Uncovering vulnerable steps in the life cycle of viruses supports the rational design of antiviral
treatments. However, information on viral replication dynamics obtained from traditional …

Arsenic has a dual role as causative and curative agent of human disease. Therefore, there
is considerable interest in elucidating arsenic toxicity and detoxification mechanisms. By an …

Zika virus (ZIKV) infection can cause important developmental and neurological defects in
Humans. Type I/III interferon responses control ZIKV infection and pathological processes, yet …

Excessive DNA damage can induce an irreversible cell cycle arrest, called senescence,
which is generally perceived as an important tumour-suppressor mechanism. However, it is …