Sestrins are stress-inducible metabolic regulators with two seemingly unrelated but physiologically
important functions: reduction of reactive oxygen species (ROS) and inhibition of the …

Absent, small, or homeotic disc1 (Ash1) is a trithorax group histone methyltransferase that is
involved in gene activation. Although there are many known histone methyltransferases, …

Epigenetic dysregulation is a prominent feature in cancer, as exemplified by frequent mutations
in chromatin regulators, including the MLL/KMT2 family of histone methyltransferases. …

Mixed lineage leukemia (MLL) family histone methyltransferases are enzymes that deposit
histone H3 Lys4 (K4) mono-/di-/tri-methylation and regulate gene expression in mammals. …

Hydrogen sulfide is a cardioprotective signaling molecule but is toxic at elevated concentrations.
Red blood cells can synthesize H 2 S but, lacking organelles, cannot dispose of H 2 S …

The influence of ethanolic extracts of Brassica campestris spp. rapa roots (EBR) on obesity
was examined in imprinting control region (ICR) mice fed a high-fat diet (HFD) and in 3T3-L1 …

Inactivation of tumor suppressor Runt-related transcription factor 3 (RUNX3) plays an
important role during early tumorigenesis. However, posttranslational modifications (PTM)-based …

For eukaryotes, fine tuning of gene expression is necessary to coordinate complex genetic
information. Recent studies have shown that noncoding RNAs (ncRNAs) play central roles in …

Cobalt–sulfur (Co–S) coordination is labile to both oxidation and reduction chemistry and is
rarely seen in nature. Cobalamin (or vitamin B 12 ) is an essential cobalt-containing …

H3K9 methylation (H3K9me) specifies the establishment and maintenance of
transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone …