An integrative genomics approach to infer causal associations between gene expression and disease
A key goal of biomedical research is to elucidate the complex network of gene interactions
underlying complex traits such as common human diseases. Here we detail a multistep …
underlying complex traits such as common human diseases. Here we detail a multistep …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …
Variations in DNA elucidate molecular networks that cause disease
Identifying variations in DNA that increase susceptibility to disease is one of the primary aims
of genetic studies using a forward genetics approach. However, identification of disease-…
of genetic studies using a forward genetics approach. However, identification of disease-…
An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome
We report a multi-omic resource generated by applying quantitative trait locus (xQTL) analyses
to RNA sequence, DNA methylation and histone acetylation data from the dorsolateral …
to RNA sequence, DNA methylation and histone acetylation data from the dorsolateral …
[PDF][PDF] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD),
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …
[HTML][HTML] Moving toward a system genetics view of disease
SK Sieberts, EE Schadt - Mammalian Genome, 2007 - Springer
Testing hundreds of thousands of DNA markers in human, mouse, and other species for
association to complex traits like disease is now a reality. However, information on how …
association to complex traits like disease is now a reality. However, information on how …
A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort
To map the genetics of gene expression in metabolically relevant tissues and investigate
the diversity of expression SNPs (eSNPs) in multiple tissues from the same individual, we …
the diversity of expression SNPs (eSNPs) in multiple tissues from the same individual, we …
[HTML][HTML] CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder
…, GE Crawford, E Domenici, B Devlin, SK Sieberts… - Scientific data, 2019 - nature.com
Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of
adults. While large-scale genetics studies have identified genomic regions associated with …
adults. While large-scale genetics studies have identified genomic regions associated with …
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Transcriptomic imputation approaches combine eQTL reference panels with large-scale
genotype data in order to test associations between disease and gene expression. These genic …
genotype data in order to test associations between disease and gene expression. These genic …
[PDF][PDF] Landscape of conditional eQTL in dorsolateral prefrontal cortex and co-localization with schizophrenia GWAS
…, BA Logsdon, JMJ Derry, KK Dang, SK Sieberts… - The American Journal of …, 2018 - cell.com
Causal genes and variants within genome-wide association study (GWAS) loci can be
identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and …
identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and …