The heterogeneous tumor microenvironment (TME) is highly complex and not entirely
understood. These complex configurations lead to the generation of oxygen-deprived conditions …

Oxygen deprivation within tumors is one of the most prevalent causes of resilient cancer cell
survival and increased immune evasion in breast cancer (BCa). Current in vitro models do …

Central nervous system atypical teratoid/rhabdoid tumors (ATRTs) are rare and aggressive
tumors with a very poor prognosis. Current treatments for ATRT include resection of the tumor…

Simple Summary We investigate the use of the small molecule epigenetic modulator 4SC-202
as a potential cancer therapeutic or adjuvant for Triple Negative Breast Cancer (TNBC). …

Lack of efficacy and a low overall success rate of phase I-II clinical trials are the most common
failures when it comes to advancing cancer treatment. Current drug sensitivity screenings …

The aim of the present study was to evaluate the possible anti-diabetic potential of Lagenaria
siceraria pulp extract (LSPE) and Lagenaria siceraria seed extract (LSSE) against the …

Background The dismal prognosis of advanced ovarian cancer calls for the development of
novel therapies to improve disease outcome. In this regard, we set out to discover new …

The fact that animal models fail to replicate human disease faithfully is now being widely
accepted by researchers across the globe. As a result, they are exploring the use of alternatives …

Oxygen deprivation within tumors is one of the most prevalent causes of resilient cancer cell
survival and increased immune evasion in breast cancer (BCa). Current in vitro models do …

Purpose: Corneal epithelial injury induces significant changes in cellular physiology of
stromal layer that results in the release of growth promoting factors to facilitate the healing. …