The marine environment is an enormous source of marine-derived natural products (MNPs),
and future investigation into anticancer drug discovery. Current progress in anticancer …

Nucleotide-binding, leucine-rich repeat receptors (NLRs) perceive pathogen effectors to
trigger plant immunity. The direct recognition mechanism of pathogen effectors by coiled-coil …

The induction of type I interferons by the bacterial secondary messengers cyclic di-GMP (c-di-GMP)
or cyclic di-AMP (c-di-AMP) is dependent on a signaling axis that involves the …

Sensing cytosolic DNA through the cGAS–STING pathway constitutes a widespread innate
immune mechanism to monitor cellular damage and microbial invasion. Evading this …

RNA helicases are involved in almost every aspect of RNA, from transcription to RNA decay.
DExD/H-box helicases comprise the largest SF2 helicase superfamily, which are …

CRISPR‐Cas systems are a form of prokaryotic adaptive immunity that employs RNA‐guided
endonucleases (Cas effectors) to cleave foreign genetic elements. Due to their simplicity, …

Diabetes mellitus is a chronic multifaceted disease with multiple potential complications, the
treatment of which can only delay and prolong the terminal stage of the disease, ie, type 2 …

STING is an essential signaling molecule for DNA and cyclic di-GMP (c-di-GMP)-mediated
type I interferon (IFN) production via TANK-binding kinase 1 (TBK1) and interferon regulatory …

Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular
DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (…

Initially isolated in 1947, Zika virus (ZIKV) has recently emerged as a significant public
health concern. Sequence analysis of all 41 known ZIKV RNA open reading frames to date …