Hematopoietic stem cell transplantation (HSCT) can replace endogenous microglia with
circulation-derived macrophages but has high mortality. To mitigate the risks of HSCT and …

Recent studies have implicated epigenetic remodeling in brain reward regions following
psychostimulant or stress exposure. It has only recently become possible to target a given type …

Chronic social defeat stress regulates the expression of Fosb in the nucleus accumbens (NAc)
to promote the cell-type-specific accumulation of ΔFosB in the two medium spiny neuron (…

Endogenous homeostatic mechanisms can restore normal neuronal function following
cocaine-induced neuroadaptations. Such mechanisms may be exploited to develop novel …

Neuronal alternative splicing is a key gene regulatory mechanism in the brain. However, the
spliceosome machinery is insufficient to fully specify splicing complexity. In considering the …

Background Sex differences in the expression and prevalence of trauma- and stress-related
disorders have led to a growing interest in the sex-specific molecular and epigenetic …

Chimeric mouse models have recently been developed to study human microglia in vivo.
However, widespread engraftment of donor microglia within the adult brain has been …

… Lombroso and Ferrero expected ideal femininity in their subjects, designated as normal, …
–1882) with the science of statistics, Lombroso and Ferrero studied the criminal, rather than the …

Alternative splicing is a key mechanism for neuronal gene regulation, and is grossly altered
in mouse brain reward regions following investigator-administered cocaine. It is well …

Background Microglia are the brain's resident macrophages. Changes in microglial state
are highly implicated in the pathogenesis of many brain diseases, but the molecular …