Loss-of-function mutations in the SCN9A gene encoding voltage-gated sodium channel Na
v 1.7 cause congenital insensitivity to pain in humans and mice. Surprisingly, many potent …

Nav1.7, a peripheral neuron voltage-gated sodium channel, is essential for pain and olfaction
in mice and humans. We examined the role of Nav1.7 as well as Nav1.3, Nav1.8, and …

Many studies support the pro-nociceptive role of brain-derived neurotrophin factor (BDNF)
in pain processes in the peripheral and central nervous system. We have previously shown …

Background: Sensory neurons play an essential role in almost all pain conditions, and have
recently been classified into distinct subsets on the basis of their transcriptomes. Here we …

Chronic pain is a major global public health issue causing a severe impact on both the
quality of life for sufferers and the wider economy. Despite the significant clinical burden, little …

Background Trigeminal neuralgia is accompanied by severe mechanical, thermal and
chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG). …

Expression of the voltage-gated sodium channel Na V 1.7 in sensory neurons is required for
pain sensation. We examined the role of Na V 1.7 in the dorsal horn of the spinal cord using …

Objective Mechanisms responsible for osteoarthritic (OA) pain remain poorly understood,
and current analgesic therapies are often insufficient. This study was undertaken to …

Chronic pain affects millions of people worldwide and new treatments are needed urgently.
One way to identify novel analgesic strategies is to understand the biological dysfunctions …

Background: Somatosensation depends on primary sensory neurons of the trigeminal and
dorsal root ganglia (DRG). Transcriptional profiling of mouse DRG sensory neurons has …