User profiles for Sonja Hänzelmann

Dr. Sonja Hänzelmann

UKE Hamburg
Verified email at uke.de
Cited by 9230

[HTML][HTML] GSVA: gene set variation analysis for microarray and RNA-seq data

S Hänzelmann, R Castelo, J Guinney - BMC bioinformatics, 2013 - Springer
Background Gene set enrichment (GSE) analysis is a popular framework for condensing
information from gene expression profiles into a pathway or signature summary. The strengths …

[PDF][PDF] Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes

T Mahdi, S Hänzelmann, A Salehi, SJ Muhammed… - Cell metabolism, 2012 - cell.com
A plethora of candidate genes have been identified for complex polygenic disorders, but the
underlying disease mechanisms remain largely unknown. We explored the pathophysiology …

The lncRNA HOTAIR impacts on mesenchymal stem cells via triple helix formation

M Kalwa, S Hänzelmann, S Otto, CC Kuo… - Nucleic acids …, 2016 - academic.oup.com
There is a growing perception that long non-coding RNAs (lncRNAs) modulate cellular
function. In this study, we analyzed the role of the lncRNA HOTAIR in mesenchymal stem cells (…

Detection of RNA–DNA binding sites in long noncoding RNAs

CC Kuo, S Hänzelmann, N Sentürk Cetin… - Nucleic acids …, 2019 - academic.oup.com
Long non-coding RNAs (lncRNAs) can act as scaffolds that promote the interaction of
proteins, RNA, and DNA. There is increasing evidence of sequence-specific interactions of …

[HTML][HTML] Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites

S Hänzelmann, F Beier, EG Gusmao, CM Koch… - Clinical …, 2015 - Springer
Background Primary cells enter replicative senescence after a limited number of cell divisions.
This process needs to be considered in cell culture experiments, and it is particularly …

Epigenetic program and transcription factor circuitry of dendritic cell development

…, EG Gusmao, S Mitzka, S Hänzelmann… - Nucleic acids …, 2015 - academic.oup.com
Dendritic cells (DC) are professional antigen presenting cells that develop from hematopoietic
stem cells through successive steps of lineage commitment and differentiation. Multipotent …

PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia

…, K Isaakidis, J Lázaro-Navarro, S Hänzelmann… - Leukemia, 2019 - nature.com
Chromosomal rearrangements and specific aneuploidy patterns are initiating events and
define subgroups in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here we …

[HTML][HTML] UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment

L Bastian, AM Hartmann, T Beder, S Hänzelmann… - Leukemia, 2022 - nature.com
Genomic aberrations—gene fusions in the majority of cases—and corresponding transcriptional
regulations define an increasingly complex landscape of molecular subtypes in B cell …

CDKN2A loss and PIK3CA mutation in myoepithelial‐like metaplastic breast cancer

…, L Mägel, A Luft, S Hänzelmann… - The Journal of …, 2018 - Wiley Online Library
Metaplastic breast carcinoma comprises a heterogeneous group of tumours with poorly
understood pathogenesis. A subset of metaplastic breast cancers show myoepithelial …

[HTML][HTML] The propagation of perturbations in rewired bacterial gene networks

R Baumstark, S Hänzelmann, S Tsuru… - Nature …, 2015 - nature.com
What happens to gene expression when you add new links to a gene regulatory network?
To answer this question, we profile 85 network rewirings in E. coli. Here we report that …