The human proteome is a crucial intermediate between complex diseases and their genetic
and environmental components, and an important source of drug development targets and …

Large genome-wide association studies (GWAS) have identified loci that are associated
with complex traits and diseases, but index variants are often not causal and reside in non-…

Background Despite a modest association between tobacco smoking and breast cancer risk
reported by recent epidemiological studies, it is still equivocal whether smoking is causally …

Background Cervical cancer (CC) screening is generally recommended until age 65. The
incidence of CC could be underestimated, particularly in older women, due to a lack of …

Background Substantial evidence supports an association between use of menopausal
hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous …

Background Dietary intake of n-3 polyunsaturated fatty acids (PUFA) may have a protective
effect on the development of cardiovascular diseases, diabetes, depression and cancer, …

Involvement of sex hormones in colorectal cancer (CRC) development has been linked to
oestrogen receptor β (ERβ). Expression of ERβ is found reduced in tumour tissue and …

Aim: Use of menopausal hormone therapy (MHT) has been associated with a reduced risk
for colorectal cancer, but mechanisms underlying this relationship are not well understood. In …

Background: High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg),
have been associated with better colorectal cancer survival. Tregs, a subset of CD4 + T …

Background: Low serum 25-hydroxyvitamin D [25(OH)D] concentrations in patients with
colorectal cancer have been consistently associated with higher mortality in observational …