User profiles for Sool Lee
 | Sool LeeUniversity of North Carolina at Chapel Hill Verified email at unc.edu Cited by 118 |
Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits
NYA Sey, B Hu, M Iskhakova, S Lee, H Sun… - Molecular …, 2022 - nature.com
Cigarette smoking and alcohol use are among the most prevalent substances used
worldwide and account for a substantial proportion of preventable morbidity and mortality, …
worldwide and account for a substantial proportion of preventable morbidity and mortality, …
Development of a blood-based transcriptional risk score for chronic obstructive pulmonary disease
Rationale: The ability of peripheral blood biomarkers to assess chronic obstructive pulmonary
disease (COPD) risk and progression is unknown. Genetics and gene expression may …
disease (COPD) risk and progression is unknown. Genetics and gene expression may …
[PDF][PDF] Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants
Genome-wide association studies (GWASs) have successfully identified 145 genomic regions
that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging to …
that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging to …
An interferon-inducible signature of airway disease from blood gene expression profiling
JH Yun, S Lee, P Srinivasa, J Morrow… - European …, 2022 - Eur Respiratory Soc
Background The molecular basis of airway remodelling in chronic obstructive pulmonary
disease (COPD) remains poorly understood. We identified gene expression signatures …
disease (COPD) remains poorly understood. We identified gene expression signatures …
[HTML][HTML] Peripheral blood microbial signatures in current and former smokers
The human microbiome has a role in the development of multiple diseases. Individual
microbiome profiles are highly personalized, though many species are shared. Understanding the …
microbiome profiles are highly personalized, though many species are shared. Understanding the …
[HTML][HTML] Improved prediction of smoking status via isoform-aware RNA-seq deep learning models
Most predictive models based on gene expression data do not leverage information related
to gene splicing, despite the fact that splicing is a fundamental feature of eukaryotic gene …
to gene splicing, despite the fact that splicing is a fundamental feature of eukaryotic gene …
Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution
Genome-wide association studies (GWAS) have identified multiple associations with
emphysema apicobasal distribution (EABD), but the biological functions of these variants are …
emphysema apicobasal distribution (EABD), but the biological functions of these variants are …
Blood RNA sequencing shows overlapping gene expression across COPD phenotype domains
Rationale COPD can be assessed using multidimensional grading systems with components
from three domains: pulmonary function tests, symptoms and systemic features. Clinically, …
from three domains: pulmonary function tests, symptoms and systemic features. Clinically, …
Clustering-based COPD subtypes have distinct longitudinal outcomes and multi-omics biomarkers
Introduction Chronic obstructive pulmonary disease (COPD) can progress across several
domains, complicating the identification of the determinants of disease progression. In our …
domains, complicating the identification of the determinants of disease progression. In our …
[HTML][HTML] Cigarette smoking-associated isoform switching and 3′ UTR lengthening via alternative polyadenylation
Cigarette smoking induces a profound transcriptomic and systemic inflammatory response.
Previous studies have focused on gene level differential expression of smoking, but the …
Previous studies have focused on gene level differential expression of smoking, but the …