[HTML][HTML] Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia

…, DR Garton, AR Montaño-Rodríguez, S Olfat… - Molecular …, 2022 - nature.com
Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in
schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized that …

Dampened amphetamine-stimulated behavior and altered dopamine transporter function in the absence of brain GDNF

…, LL Porokuokka, K Varendi, S Olfat… - Journal of …, 2017 - Soc Neuroscience
Midbrain dopamine neuron dysfunction contributes to various psychiatric and neurological
diseases, including drug addiction and Parkinson's disease. Because of its well established …

Increased Physiological GDNF Levels Have No Effect on Dopamine Neuron Protection and Restoration in a Proteasome Inhibition Mouse Model of Parkinson's …

S Olfat, K Mätlik, JJ Kopra, DR Garton, VH Iivanainen… - Eneuro, 2023 - eneuro.org
Parkinson’s disease (PD) is a progressive neurodegenerative disease that comprises a
range of motor and nonmotor symptoms. Glial cell line-derived neurotrophic factor (GDNF) …

Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF

…, Y Gui, E Siefker, B Lu, K Mätlik, S Olfat… - …, 2021 - journals.biologists.com
Nephron endowment, defined during the fetal period, dictates renal and related cardiovascular
health throughout life. We show here that, despite its negative effects on kidney growth, …

Granulocyte‐macrophage colony‐stimulating factor, a potent adjuvant for polarization to Th‐17 pattern: an experience on HIV‐1 vaccine model

…, HR Moozarmpour, MS Beikverdi, S Olfat… - Apmis, 2017 - Wiley Online Library
Cytokines are mediators for polarization of immune response in vaccines. Studies show that
co‐immunization of DNA vaccines with granulocyte‐macrophage colony‐stimulating factor (…

[HTML][HTML] Selective targeting of striatal parvalbumin-expressing interneurons for transgene delivery

MD Azevedo, S Sander, C Jeanneret, S Olfat… - Journal of Neuroscience …, 2021 - Elsevier
PV Cre mice--> combined with AAV-FLEX vectors allowed efficient and specific targeting of
PV + interneurons in the striatum. However, diffusion of viral particles to the globus pallidus …

[PDF][PDF] In vivo modulation of endogenous gene expression via CRISPR/Cas9-mediated 3'UTR editing

K Mätlik, S Olfat, MC Cowlishaw, ED Moreno, S Ollila… - Heliyon, 2023 - cell.com
The 3' untranslated regions (UTRs) modulate gene expression levels by regulating mRNA
stability and translation. We previously showed that the replacement of the negative …

Nicotinamide riboside alleviates Parkinson's disease symptoms but downregulates dopamine metabolism upon lactacystin-induced proteostasis failure

G Turconi, F Alam, T SenGupta, S Pirnes-Karhu, S Olfat… - bioRxiv, 2021 - biorxiv.org
Activation of mitochondrial metabolism and proteostasis with the NAD + precursor nicotinamide
riboside (NR) has emerged as a potential therapeutic approach for neurodegenerative …

Gene Knock Up via 3'UTR editing to study gene function in vivo

K Mätlik, S Olfat, DR Garton, A Montaño-Rodriguez… - bioRxiv, 2019 - biorxiv.org
Currently available genetic tools do not allow researchers to upregulate (‘Knock Up’) the
levels of a given protein while retaining its cell-type-specific regulation. As a result, we have …

Tumor-free elongation of mammalian nephrogenesis by excess fetal GDNF

H Li, J Kupari, Y Gui, E Siefker, B Lu, K Mätlik, S Olfat… - bioRxiv, 2020 - biorxiv.org
Due to poor regenerative capacity of adult kidneys, nephron endowment defined by the
nephrogenic program during the fetal period dictates renal and related cardiovascular health …