[HTML][HTML] Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia
…, DR Garton, AR Montaño-Rodríguez, S Olfat… - Molecular …, 2022 - nature.com
Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in
schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized that …
schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized that …
Dampened amphetamine-stimulated behavior and altered dopamine transporter function in the absence of brain GDNF
…, LL Porokuokka, K Varendi, S Olfat… - Journal of …, 2017 - Soc Neuroscience
Midbrain dopamine neuron dysfunction contributes to various psychiatric and neurological
diseases, including drug addiction and Parkinson's disease. Because of its well established …
diseases, including drug addiction and Parkinson's disease. Because of its well established …
Increased Physiological GDNF Levels Have No Effect on Dopamine Neuron Protection and Restoration in a Proteasome Inhibition Mouse Model of Parkinson's …
S Olfat, K Mätlik, JJ Kopra, DR Garton, VH Iivanainen… - Eneuro, 2023 - eneuro.org
Parkinson’s disease (PD) is a progressive neurodegenerative disease that comprises a
range of motor and nonmotor symptoms. Glial cell line-derived neurotrophic factor (GDNF) …
range of motor and nonmotor symptoms. Glial cell line-derived neurotrophic factor (GDNF) …
Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF
Nephron endowment, defined during the fetal period, dictates renal and related cardiovascular
health throughout life. We show here that, despite its negative effects on kidney growth, …
health throughout life. We show here that, despite its negative effects on kidney growth, …
Granulocyte‐macrophage colony‐stimulating factor, a potent adjuvant for polarization to Th‐17 pattern: an experience on HIV‐1 vaccine model
…, HR Moozarmpour, MS Beikverdi, S Olfat… - Apmis, 2017 - Wiley Online Library
Cytokines are mediators for polarization of immune response in vaccines. Studies show that
co‐immunization of DNA vaccines with granulocyte‐macrophage colony‐stimulating factor (…
co‐immunization of DNA vaccines with granulocyte‐macrophage colony‐stimulating factor (…
[HTML][HTML] Selective targeting of striatal parvalbumin-expressing interneurons for transgene delivery
MD Azevedo, S Sander, C Jeanneret, S Olfat… - Journal of Neuroscience …, 2021 - Elsevier
PV Cre mice--> combined with AAV-FLEX vectors allowed efficient and specific targeting of
PV + interneurons in the striatum. However, diffusion of viral particles to the globus pallidus …
PV + interneurons in the striatum. However, diffusion of viral particles to the globus pallidus …
[PDF][PDF] In vivo modulation of endogenous gene expression via CRISPR/Cas9-mediated 3'UTR editing
The 3' untranslated regions (UTRs) modulate gene expression levels by regulating mRNA
stability and translation. We previously showed that the replacement of the negative …
stability and translation. We previously showed that the replacement of the negative …
Nicotinamide riboside alleviates Parkinson's disease symptoms but downregulates dopamine metabolism upon lactacystin-induced proteostasis failure
G Turconi, F Alam, T SenGupta, S Pirnes-Karhu, S Olfat… - bioRxiv, 2021 - biorxiv.org
Activation of mitochondrial metabolism and proteostasis with the NAD + precursor nicotinamide
riboside (NR) has emerged as a potential therapeutic approach for neurodegenerative …
riboside (NR) has emerged as a potential therapeutic approach for neurodegenerative …
Gene Knock Up via 3'UTR editing to study gene function in vivo
K Mätlik, S Olfat, DR Garton, A Montaño-Rodriguez… - bioRxiv, 2019 - biorxiv.org
Currently available genetic tools do not allow researchers to upregulate (‘Knock Up’) the
levels of a given protein while retaining its cell-type-specific regulation. As a result, we have …
levels of a given protein while retaining its cell-type-specific regulation. As a result, we have …
Tumor-free elongation of mammalian nephrogenesis by excess fetal GDNF
Due to poor regenerative capacity of adult kidneys, nephron endowment defined by the
nephrogenic program during the fetal period dictates renal and related cardiovascular health …
nephrogenic program during the fetal period dictates renal and related cardiovascular health …