More than 50% of mammalian genomes consist of retrotransposon sequences. Silencing of
retrotransposons by heterochromatin is essential to ensure genomic stability and …

Endogenous retroviruses (ERV) are an abundant class of repetitive elements in mammalian
genomes. To ensure genomic stability, ERVs are largely transcriptionally silent. However, …

Pioneer transcription factors (PTF) can recognize their binding sites on nucleosomal DNA
and trigger chromatin opening for recruitment of other non-pioneer transcription factors. …

Endogenous retroviruses (ERVs) comprise a significant portion of mammalian genomes.
Although specific ERV loci feature regulatory roles for host gene expression, most ERV …

Background Nuclear localization of Gag is a property shared by many retroviruses and
retrotransposons. The importance of this stage for retroviral replication is still unknown, but …

Background Dicer is an RNase III-ribonuclease that initiates the formation of small interfering
RNAs as a defence against genomic parasites such as retrotransposons. Despite intensive …

Background Retroviruses encode a very limited number of proteins and therefore must exploit
a wide variety of host proteins for completion of their lifecycle. Methods We performed an …

Cancer arises from a series of genetic and epigenetic changes, which result in abnormal
expression or mutational activation of oncogenes, as well as suppression/inactivation of tumor …

… August Groh was the third child of Christian Karl Gottfried Groh and his wife Sophia (Bodenchatz)
Groh. … Groh had built their home which still stands at 731 Noble. He was a paperhanger …

The positioning performance of global navigation satellite systems (GNSSs) mass market
receivers severely degrades when the received satellite signals are subject to multipath …