A tethered ligand assay to probe SARS-CoV-2: ACE2 interactions
MS Bauer, S Gruber, A Hausch… - Proceedings of the …, 2022 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are initiated by
attachment of the receptor-binding domain (RBD) on the viral Spike protein to angiotensin-…
attachment of the receptor-binding domain (RBD) on the viral Spike protein to angiotensin-…
Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor
…, PU Walker, SM Sedlak, S Gruber… - Proceedings of the …, 2019 - National Acad Sciences
Single-molecule force spectroscopy has provided unprecedented insights into protein
folding, force regulation, and function. So far, the field has relied primarily on atomic force …
folding, force regulation, and function. So far, the field has relied primarily on atomic force …
Single-molecule force stability of the SARS-CoV-2–ACE2 interface in variants-of-concern
Mutations in SARS-CoV-2 have shown effective evasion of population immunity and increased
affinity to the cellular receptor angiotensin-converting enzyme 2 (ACE2). However, in the …
affinity to the cellular receptor angiotensin-converting enzyme 2 (ACE2). However, in the …
A conformational transition of the D′ D3 domain primes von Willebrand factor for multimerization
S Gruber, A Löf, A Hausch, F Kutzki, R Jöhr… - Blood …, 2022 - ashpublications.org
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that is critically involved in
hemostasis. Biosynthesis of long VWF concatemers in the endoplasmic reticulum and the …
hemostasis. Biosynthesis of long VWF concatemers in the endoplasmic reticulum and the …
Designed anchoring geometries determine lifetimes of biotin–streptavidin bonds under constant load and enable ultra-stable coupling
S Gruber, A Löf, SM Sedlak, M Benoit, HE Gaub… - Nanoscale, 2020 - pubs.rsc.org
The small molecule biotin and the homotetrameric protein streptavidin (SA) form a stable and
robust complex that plays a pivotal role in many biotechnological and medical applications. …
robust complex that plays a pivotal role in many biotechnological and medical applications. …
[PDF][PDF] The Low-Force Response of Von Willebrand Factor Revealed by Magnetic Tweezers
S Gruber, A Löf, T Obser, MA Brehm, M Benoit… - Biophysical …, 2020 - cell.com
Wednesday, February 19, 2020 619a the force range accessible by most methods of single-molecule
force spectroscopy. We established an assay based on magnetic tweezers that …
force spectroscopy. We established an assay based on magnetic tweezers that …
A tethered ligand assay to probe the SARS-CoV-2 ACE2 interaction under constant force
The current COVID-19 pandemic has a devastating global impact and is caused by the
SARS-CoV-2 virus. SARS-CoV-2 attaches to human host cells through interaction of its receptor …
SARS-CoV-2 virus. SARS-CoV-2 attaches to human host cells through interaction of its receptor …
A Conformational Transition of Von Willebrand Factor's D'D3 Domain Primes It For Multimerization
S Gruber, A Löf, A Hausch, R Jöhr, T Obser, G König… - bioRxiv, 2021 - biorxiv.org
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that is critically involved in
hemostasis. Biosynthesis of long VWF concatemers in the endoplasmic reticulum and the (…
hemostasis. Biosynthesis of long VWF concatemers in the endoplasmic reticulum and the (…
[HTML][HTML] VR in Nursing Facilities-A randomized controlled multicenter pilot study analyzing the changes in the state of mind of seniors in nursing facilities through the …
SS Gruber, A Weigel, T Tischendorf, T Schaal… - Journal of Public …, 2022 - Springer
Context VR as an application to enhance well-being is sparsely researched in the elderly
population. The aim of the pilot study was to analyze the effect of 360 videos of different …
population. The aim of the pilot study was to analyze the effect of 360 videos of different …
Effects of Variants of Concern Mutations on the Force-Stability of the SARS-CoV-2: ACE2 Interface and Virus Transmissibility
Viruses mutate under a variety of selection pressures, allowing them to continuously adapt to
their hosts. Mutations in SARS-CoV-2 have shown effective evasion of population immunity …
their hosts. Mutations in SARS-CoV-2 have shown effective evasion of population immunity …