Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury

LE Gralinski, A Bankhead III, S Jeng, VD Menachery… - MBio, 2013 - Am Soc Microbiol
ABSTRACT Systems biology offers considerable promise in uncovering novel pathways by
which viruses and other microbial pathogens interact with host signaling and expression …

[PDF][PDF] Cytomegalovirus miRNAs target secretory pathway genes to facilitate formation of the virion assembly compartment and reduce cytokine secretion

…, R Tirabassi, T Doyle, M Hancock, I Landais, S Jeng… - Cell host & …, 2014 - cell.com
Herpesviruses, including human cytomegalovirus (HCMV), encode multiple microRNAs (miRNA)
whose targets are just being uncovered. Moreover, miRNA function during the virus life …

A microRNA screen identifies the Wnt signaling pathway as a regulator of the interferon response during flavivirus infection

JL Smith, S Jeng, SK McWeeney, AJ Hirsch - Journal of virology, 2017 - Am Soc Microbiol
The impact of mosquito-borne flavivirus infections worldwide is significant, and many critical
aspects of these viruses' biology, including virus-host interactions, host cell requirements for …

Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

…, B Olson, KA Michaelis, ERS Torres, S Jeng… - Elife, 2020 - elifesciences.org
Weight loss and anorexia are common symptoms in cancer patients that occur prior to
initiation of cancer therapy. Inflammation in the brain is a driver of these symptoms, yet cellular …

[HTML][HTML] Maternal high-fat diet and obesity compromise fetal hematopoiesis

…, X Zhu, QR Roth-Carter, PR Levasseur, S Jeng… - Molecular …, 2015 - Elsevier
Objective Recent evidence indicates that the adult hematopoietic system is susceptible to
diet-induced lineage skewing. It is not known whether the developing hematopoietic system is …

[PDF][PDF] In vivo repair of a protein underlying a neurological disorder by programmable RNA editing

…, SY Kim, JR Fisk, Z Song, H Nakai, S Jeng… - Cell reports, 2020 - cell.com
Programmable RNA editing is gaining momentum as an approach to repair mutations, but
its efficiency in repairing endogenous mutant RNA in complex tissue is unknown. Here we …

REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation–differentiation balance in the developing brain

CE Monaghan, T Nechiporuk, S Jeng… - Proceedings of the …, 2017 - National Acad Sciences
The transcriptional events that lead to the cessation of neural proliferation, and therefore
enable the production of proper numbers of differentiated neurons and glia, are still largely …

Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus

C Li, A Bankhead III, AJ Eisfeld, Y Hatta, S Jeng… - Journal of …, 2011 - Am Soc Microbiol
During the last decade, more than half of humans infected with highly pathogenic avian
influenza (HPAI) H5N1 viruses have died, yet virus-induced host signaling has yet to be clearly …

Targeted RNA editing in brainstem alleviates respiratory dysfunction in a mouse model of Rett syndrome

…, JF Yung, JR Fisk, S Jeng… - Proceedings of the …, 2022 - National Acad Sciences
Rett syndrome is a neurological disease due to loss-of-function mutations in the transcription
factor, Methyl CpG binding protein 2 (MECP2). Because overexpression of endogenous …

[PDF][PDF] Extensive homeostatic T cell phenotypic variation within the Collaborative Cross

JB Graham, JL Swarts, M Mooney, G Choonoo, S Jeng… - Cell reports, 2017 - cell.com
The Collaborative Cross (CC) is a panel of reproducible recombinant inbred mouse strains
with high levels of standing genetic variation, affording an unprecedented opportunity to …