Highlights • This review re-explores the comparison between phenotypic and target-based
drug discovery and outlines how machine learning (ML) can assist the former at the forefront …

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) enable human
cardiac cells to be studied in vitro, although they use glucose as their primary metabolic …

The heart is a metabolic omnivore and the adult heart selects the substrate best suited for
each circumstance, with fatty acid oxidation preferred in order to fulfill the high energy demand …

During heart development, epicardial cells residing within the outer layer undergo epithelial-mesenchymal
transition (EMT) and migrate into the underlying myocardium to support …

Cardiosphere-derived cells (CDCs), which can be isolated from heart explants, are a promising
candidate cell source for infarcted myocardium regeneration. However, current protocols …

When stressed by ageing or disease, the adult human heart is unable to regenerate, leading
to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has …

Myocardial infarction is the most prevalent of cardiovascular diseases and pharmacological
interventions do not lead to restoration of the lost cardiomyocytes. Despite extensive stem …

Mesenchymal cells are a promising candidate cell source for restoring lost tissue and thereby
preventing heart failure. In the clinic, cells are isolated from patients who may be suffering …

Based on data from the World Healthcare Organisation, cardiovascular diseases are the
primary cause of disease-related death globally, with myocardial infarction (MI) being the most …

Cardiosphere-derived cells (CDCs), which can be isolated from heart explants, are a promising
candidate cell source for infarcted myocardium regeneration. However, current protocols …