Sedentary behavior has a strong association with cardiovascular disease (CVD) risk, which
may be independent of physical activity. To date, the mechanism (s) that mediate this …

The prevalence of obstructive sleep apnea (OSA) continues to rise. So too do the health,
safety, and economic consequences. On an individual level, the causes and consequences of …

Sedentary behaviour — put simply, too much sitting, as a distinct concept from too little
exercise — is a novel determinant of cardiovascular risk. This definition provides a perspective …

Decreased cerebrovascular blood flow and function are associated with lower cognitive
functioning and increased risk of neurodegenerative diseases. Prolonged sitting impairs …

Background Pulmonary arterial hypertension ( PAH ) is a vasculopathy characterized by
enhanced pulmonary artery smooth muscle cell ( PASMC ) proliferation and suppressed …

Advancing age may be the most potent independent predictor of future cardiovascular
events, a relationship that is not fully explained by time‐related changes in traditional …

Obesity is a global epidemic associated with aging-like cellular processes; in both aging
and obesity, resistance to hormones such as insulin and leptin can be observed. Leptin is a …

Targeted genome editing enables the creation of bona fide cellular models for biological
research and may be applied to human cell-based therapies. Therefore, broadly applicable and …

Study Objectives To determine the effects of the nonbenzodiazepine sedative zopiclone on
the threshold to arousal with increasing respiratory effort and genioglossus muscle activity …

Impaired upper airway anatomy is the main cause of obstructive sleep apnea (OSA). However,
there are other important non-anatomical contributors or “endotypes” including ventilatory …