The CRISPR-associated endonuclease Cas9 can be targeted to specific genomic loci by
single guide RNAs (sgRNAs). Here, we report the crystal structure of Streptococcus pyogenes …

Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-…

Transcriptomic profiling of complex tissues by single-nucleus RNA-sequencing (snRNA-seq)
affords some advantages over single-cell RNA-sequencing (scRNA-seq). snRNA-seq …

We describe convergent evidence from transcriptomics, morphology, and physiology for a
specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus RNA …

The diverse progenitors that give rise to the human neocortex have been difficult to
characterize because progenitors, particularly radial glia (RG), are rare and are defined by a …

During human brain development, multiple signaling pathways generate diverse cell types
with varied regional identities. Here, we integrate single-cell RNA sequencing and clonal …

Abundant evidence supports the presence of at least three distinct types of thalamocortical (TC)
neurons in the primate dorsal lateral geniculate nucleus (dLGN) of the thalamus, the …

von Economo neurons (VENs) are bipolar, spindle-shaped neurons restricted to layer 5 of
human frontoinsula and anterior cingulate cortex that appear to be selectively vulnerable to …

GABAergic interneurons are essential for neural circuit function, and their loss or dysfunction
is implicated in human neuropsychiatric disease. In vitro methods for interneuron …

Nsp1 is a SARS-CoV-2 host shutoff factor that both represses cellular translation and
promotes host RNA decay. However, it is unclear how these two activities are connected and …