Low levels of oxygen or hypoxia is often an obstacle in health, particularly in pathological
disorders like cancer. The main family of transcription factors responsible for cell survival and …

Genetic heterogeneity between and within tumours is a major factor determining cancer
progression and therapy response. Here we examined DNA sequence and DNA copy-number …

Erythropoiesis must be tightly balanced to guarantee adequate oxygen delivery to all tissues
in the body. This process relies predominantly on the hormone erythropoietin (EPO) and its …

Virtually all solid tumors are dependent on a vascular network to provide them with the right
amount of nutrients and oxygen. In that sense, low oxygen tension or hypoxia leads to an …

Background β-catenin activation plays a crucial role for tumourigenesis in the large intestine
but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin …

In colorectal cancer, oncogenic mutations transform a hierarchically organized and homeostatic
epithelium into invasive cancer tissue lacking visible organization. We sought to define …

Background Pancreatic neuroendocrine neoplasms (PanNENs) fall into two subclasses: the
well-differentiated, low- to high-grade pancreatic neuroendocrine tumors (PanNETs), and …

Pulmonary enteric adenocarcinoma is a rare non-small cell lung cancer subtype. It is poorly
characterized and cannot be distinguished from metastatic colorectal or upper …

Skin wound healing in mammals is a complex, multicellular process that depends on the
precise supply of oxygen. Hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) serves as …

Hypoxia is a prominent feature in the maintenance of hematopoietic stem cell (HSC) quiescence
and multipotency. Hypoxia-inducible factor (HIF) prolyl hydroxylase domain proteins (…