We present TrackMate, an open source Fiji plugin for the automated, semi-automated, and
manual tracking of single-particles. It offers a versatile and modular solution that works out of …

Particle tracking is of key importance for quantitative analysis of intracellular dynamic
processes from time-lapse microscopy image data. Because manually detecting and following …

The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …

Malaria is contracted when Plasmodium sporozoites are inoculated into the vertebrate host
during the blood meal of a mosquito. In infected mosquitoes, sporozoites are present in large …

Modern drug discovery approaches often use high-content imaging to systematically study
the effect on cells of large libraries of chemical compounds. By automatically screening …

Background Microglial cells are tissue-resident macrophages of the central nervous system.
They are extremely dynamic, sensitive to their microenvironment and present a …

Background Skeletal muscle has the capacity to adapt to environmental changes and
regenerate upon injury. To study these processes, most experimental methods use quantification …

Shigella enters epithlial cells via internalization into a vacuole. Subsequent vacuolar membrane
rupture allows bacterial escape into the cytosol for replication and cell-to-cell spread. …

Cell-based phenotypic screening has proven to be valuable, notably in recapitulating
relevant biological conditions, for example, the host cell/pathogen niche. However, the …

Intracellular replication of Salmonella enterica occurs in membrane‐bound compartments,
called Salmonella‐containing vacuoles (SCVs). Following invasion of epithelial cells, most …