Genetically encoded calcium indicators (GECIs) can be used to image activity in defined
neuronal populations. However, current GECIs produce inferior signals compared to synthetic …

Although many properties of the nervous system are shared among animals and systems, it
is not known whether different neuronal circuits use common strategies to guide behaviour. …

Innate social behaviours emerge from neuronal circuits that interpret sensory information on
the basis of an individual’s own genotype, sex and experience. The regulated aggregation …

A major challenge in neuroscience is to reliably activate individual neurons, particularly
those in deeper brain regions. Current optogenetic approaches require invasive surgical …

Many neurons release classical transmitters together with neuropeptide co-transmitters
whose functions are incompletely understood. Here we define the relationship between two …

Altering the concentrations of cyclic nucleotides within nerve cells can dramatically change
their responses to axonal guidance cues, but the physiological signals that might induce …

Scanning Electron Microscopy (SEM) has long been the standard in imaging the sub-micrometer
surface ultrastructure of both hard and soft materials. In the case of biological samples, …

Innate chemosensory preferences are often encoded by sensory neurons that are
specialized for attractive or avoidance behaviors. Here, we show that one olfactory neuron in …

10.7554/eLife.04220.001 Animals have evolved intricate search strategies to find new
sources of food. Here, we analyze a complex food seeking behavior in the nematode …

Ultrasound has been used to non-invasively manipulate neuronal functions in humans and
other animals. However, this approach is limited as it has been challenging to target specific …