A comprehensive high-resolution targeted workflow for the deep profiling of sphingolipids

B Peng, ST Weintraub, C Coman, S Ponnaiyan… - Analytical …, 2017 - ACS Publications
Sphingolipids make up a highly diverse group of biomolecules that not only are membrane
components but also are involved in various cellular functions such as signaling and protein …

[HTML][HTML] Multi–Cell Line Analysis of Lysosomal Proteomes Reveals Unique Features and Novel Lysosomal Proteins

F Akter, S Bonini, S Ponnaiyan… - Molecular & Cellular …, 2023 - ASBMB
Lysosomes, the main degradative organelles of mammalian cells, play a key role in the
regulation of metabolism. It is becoming more and more apparent that they are highly active, …

[HTML][HTML] Transcriptional coexpression network reveals the involvement of varying stem cell features with different dysregulations in different gastric cancer subtypes

…, J Periasamy, DB Rao, GD Barnabas, S Ponnaiyan… - Molecular …, 2014 - Elsevier
Despite the advancements in the cancer therapeutics, gastric cancer ranks as the second
most common cancers with high global mortality rate. Integrative functional genomic …

[HTML][HTML] Comprehensive draft of the mouse embryonic fibroblast lysosomal proteome by mass spectrometry based proteomics

S Ponnaiyan, F Akter, J Singh, D Winter - Scientific Data, 2020 - nature.com
Lysosomes are the main degradative organelles of cells and involved in a variety of
processes including the recycling of macromolecules, storage of compounds, and metabolic …

Generation of antibodies targeting cleavable cross-linkers

J Singh, S Ponnaiyan, V Gieselmann… - Analytical …, 2021 - ACS Publications
Chemical cross-linking has become a powerful tool for the analysis of protein structures and
interactions by mass spectrometry. A particular strength of this approach is the ability to …

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KM Kelly, E Yenser - ASBMB
In Brief Ovarian cancer is the most lethal malignant gynecological tumor, and the clinical
diagnosis and treatment of OC have always been difficult. Cancer cell–derived exosomes play …

[HTML][HTML] Targeted quantification of the lysosomal proteome in complex samples

P Mosen, A Sanner, J Singh, D Winter - Proteomes, 2021 - mdpi.com
… The authors would like to thank Robert Hardt for helpful discussions, Shiva Ahmadi for help
with liver samples, and Fatema Akter as well as Srigayatri Ponnaiyan for help with lysosome-…

[PDF][PDF] Targeted Quantification of the Lysosomal Proteome in Complex Samples. Proteomes 2021, 9, 4

P Mosen, A Sanner, J Singh, D Winter - 2021 - pdfs.semanticscholar.org
… Acknowledgments: The authors would like to thank Robert Hardt for helpful discussions,
Shiva Ahmadi for help with liver samples, and Fatema Akter as well as Srigayatri Ponnaiyan for …

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

GA Wyant, M Abu-Remaileh, EM Frenkel, NN Laqtom… - Science, 2018 - science.org
The lysosome degrades and recycles macromolecules, signals to the master growth regulator
mTORC1 [mechanistic target of rapamycin (mTOR) complex 1], and is associated with …

Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex

RE Lawrence, SA Fromm, Y Fu, AL Yokom, DJ Kim… - Science, 2019 - science.org
The tumor suppressor folliculin (FLCN) enables nutrient-dependent activation of the
mechanistic target of rapamycin complex 1 (mTORC1) protein kinase via its guanosine …