Recurrent medulloblastoma and ependymoma are universally lethal, with no approved
targeted therapies and few candidates presently under clinical evaluation. Nearly all recurrent …

Canonical (H3.1/H3.2) and noncanonical (H3.3) histone 3 K27M-mutant gliomas have unique
spatiotemporal distributions, partner alterations and molecular profiles. The contribution of …

Ependymomas are aggressive brain tumors. Although drivers of supratentorial ependymoma
( ZFTA - and YAP1 -associated gene fusions) have been discovered, their functions remain …

Diffuse midline gliomas (DMGs) bearing driver mutations of histone 3 lysine 27 (H3K27M)
are incurable brain tumors with unique epigenomes. Here, we generated a syngeneic …

The Gasterosteidae fish family hosts several species that are important models for eco-evolutionary,
genetic, and genomic research. In particular, a wealth of genetic and genomic data …

Ependymomas are hard-to-treat brain tumors driven by translocations between ZFTA and a
variety of transcriptional coactivators. We dissect the transforming mechanism of these fusion …

Whole-genome duplication (WGD) has been a major evolutionary driver of increased genomic
complexity in vertebrates. One such event occurred in the salmonid family ∼80 Ma (Ss4R…

Atlantic cod (Gadus morhua) is an ecologically important species with a wide‐spread
distribution in the North Atlantic Ocean, yet little is known about the diversity of its intestinal …

The relative importance of host-specific selection or environmental factors in determining
the composition of the intestinal microbiome in wild vertebrates remains poorly understood. …

Epigenetic dysregulation is a universal feature of cancer that results in altered patterns of
gene expression that drive malignancy. Brain tumors exhibit subtype-specific epigenetic …