The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging
across many parts of Africa. Resistance to existing drugs was emerging, and many programs …

The persistence of Mycobacterium tuberculosis despite prolonged chemotherapy represents
a major obstacle for the control of tuberculosis. The mechanisms used by Mtb to persist in a …

New therapeutic strategies are needed to combat the tuberculosis pandemic and the spread
of multidrug-resistant (MDR) and extensively drug-resistant (XDR) forms of the disease, …

Chagas disease, leishmaniasis and sleeping sickness affect 20 million people worldwide
and lead to more than 50,000 deaths annually 1 . The diseases are caused by infection with …

The ability of Mycobacterium tuberculosis to persist in its human host despite extensive
chemotherapy is thought to be based on subpopulations of non-replicating phenotypically drug-…

Candidate antibacterials are usually identified on the basis of their in vitro activity. However,
the apparent inhibitory activity of new leads can be misleading because most culture media …

While prevention is a bedrock of public health, innovative therapeutics are needed to
complement the armamentarium of interventions required to achieve disease control and …

Target practice: The target of the antibiotic cyclomarin A was identified in Mycobacterium.
Cyclomarin A (see structure) binds the regulatory subunit of the Clp protease complex with …

New chemotherapeutic compounds against multidrug-resistant Mycobacterium tuberculosis
(Mtb) are urgently needed to combat drug resistance in tuberculosis (TB). We have identified …

… Srinivasa PS Rao Srinivasa PS Rao … Manjunatha, Véronique Dartois, Thomas Dick, Srinivasa
PS Rao, Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB …