Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes
during fetal and postnatal development. Mammals have four Notch receptors that bind five …

β-catenin–mediated Wnt signaling has been suggested to be critically involved in
hematopoietic stem cell maintenance and development of T and B cells in the immune system. …

Jagged1-mediated Notch signaling has been suggested to be critically involved in
hematopoietic stem cell (HSC) self-renewal. Unexpectedly, we report here that inducible Cre-loxP–…

After birth, the development of hematopoietic cells occurs in the bone marrow. Hematopoietic
differentiation is finely tuned by cell-intrinsic mechanisms and lineage-specific transcription …

Knowledge about the hematopoietic niche has evolved considerably in recent years, in
particular through in vitro analyzes, mouse models and the use of xenografts. Its complexity in …

In the bone marrow (BM), stromal cells constitute a supportive tissue indispensable for the
generation of pro-B/pre-BI, pre-BII, and immature B lymphocytes. IL-7–producing stromal cells …

B-cell development is dependent on the interactions between B-cell precursors and bone
marrow stromal cells, but the role of osteoclasts (OCLs) in this process remains unknown. B …

Activation of the pre-B-cell receptor (pre-BCR) in the bone marrow depends on both tonic
and ligand-induced signaling and leads to pre-BII-cell proliferation and differentiation. Using …

WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations.
Here we report a decrease in bone mineral density in 25% of WHIM patients and bone …

In the bone marrow, CXCL12 and IL-7 are essential for B cell differentiation, whereas
hematopoietic stem cell (HSC) maintenance requires SCF and CXCL12. Peri-sinusoidal stromal (…