Abstract Specification of cell identity during development depends on exposure of cells to
sequences of extrinsic cues delivered at precise times and concentrations. Identification of …

We report that Emx2 homeogene is expressed at the mRNA and protein levels in the adult
mouse olfactory neuroepithelium. As expected for a transcription factor, Emx2 is present in the …

Bone morphogenetic proteins (BMPs) are secreted regulators of cell fate in several developing
tissues. In the embryonic spinal cord, they control the emergence of the neural crest, roof …

Formation of functional motor circuits relies on the ability of distinct spinal motor neuron subtypes
to project their axons with high precision to appropriate muscle targets. While guidance …

Integrated in vitro models of human organogenesis are needed to elucidate the multi-systemic
events underlying development and disease. Here we report the generation of human …

Spinal motor neurons (MNs) integrate sensory stimuli and brain commands to generate
movements. In vertebrates, the molecular identities of the cardinal MN types such as those …

Alternative splicing (AS) is a key process underlying the expansion of proteomic diversity
and the regulation of gene expression. Here, we identify an evolutionarily conserved …

Efficient transcriptional programming promises to open new frontiers in regenerative medicine.
However, mechanisms by which programming factors transform cell fate are unknown, …

Rostro-caudal patterning of vertebrates depends on the temporally progressive activation of
HOX genes within axial stem cells that fuel axial embryo elongation. Whether the pace of …

Stable genomic integration of exogenous transgenes is essential in neurodevelopmental
and stem cell studies. Despite tools driving increasingly efficient genomic insertion with DNA …