Background: Kinase Suppressor of Ras (KSR) is a conserved component of the Ras pathway
that acts as a molecular scaffold to facilitate signal transmission through the MAPK cascade…

Kinase suppressor of Ras (KSR) is a conserved component of the Ras pathway that interacts
directly with MEK and MAPK. Here we show that KSR1 translocates from the cytoplasm to …

Osteoclast maturation is accompanied by changes in podosome patterning, resulting in the
formation of a peripheral belt, which requires an intact microtubule network. Here, we report …

Metabolic health depends on the brain’s ability to control food intake and nutrient use versus
storage, processes that require peripheral signals such as the adipocyte-derived hormone, …

Cells from the myeloid lineage, namely macrophages, dendritic cells and osteoclasts,
develop podosomes instead of stress fibers and focal adhesions to adhere and migrate. …

Rho GTPases are well known regulators of the actin cytoskeleton that act by binding and
activating actin nucleators. They are therefore involved in many actin-based processes, …

Multinucleated giant cells (MNGC) derived from avian blood monocytes present, like
osteoclasts, an unusual cytoskeletal organization characterized by (1) cortical rings of actin …

Efficient T cell activation requires at least two signals, one mediated by the engagement of
the TCR-CD3 complex and another one mediated by a costimulatory molecule. We recently …

RhoGTPases regulate actin cytoskeleton dynamics, a key element in osteoclast biology. We
identified three novel genes induced during RANKL‐stimulated osteoclastogenesis among …

Over the past years, dynamin has been implicated in tuning the amount and nature of
transmitter released during exocytosis. However, the mechanism involved remains poorly …