RESEARCH Page 1 RESEARCH The clinical importance of white matter hyperintensities on
brain magnetic resonance imaging: systematic review and meta-analysis Stéphanie Debette…

Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits (systolic, diastolic …

Spontaneous intracranial artery dissection is an uncommon and probably underdiagnosed
cause of stroke that is defined by the occurrence of a haematoma in the wall of an intracranial …

Importance Covert vascular brain injury (VBI) is highly prevalent in community-dwelling
older persons, but its clinical and therapeutic implications are debated. Objective To better …

White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral
small vessel disease (SVD), hypertension being the main known risk factor. Here, we …

Background The genes underlying the risk of stroke in the general population remain
undetermined. Methods We carried out an analysis of genomewide association data generated …

Background and Purpose— The widespread preference of anticoagulants over antiplatelets
in patients with cervical artery dissection (CAD) is empirical rather than evidence-based. …

Objective: Our aim was to test the association of vascular risk factor exposure in midlife with
progression of MRI markers of brain aging and measures of cognitive decline. Methods: A …

Objective Midlife obesity has been associated with an increased risk of dementia. The
underlying mechanisms are poorly understood. Our aim was to examine the cross‐sectional …