During wakefulness, pyramidal neurons in the intact brain are bombarded by synaptic input
that causes tonic depolarization, increased membrane conductance (ie, shunting), and noisy …

The membrane conductance of a pyramidal neuron in vivo is substantially increased by
background synaptic input. Increased membrane conductance, or shunting, does not simply …

Hippocampal CA1 inhibitory interneurones control the excitability and synchronization of
pyramidal cells, and participate in hippocampal synaptic plasticity. Pairing theta‐burst …

Electrically activating mechanoreceptive afferents inhibits pain. However, paresthesia
evoked by spinal cord stimulation (SCS) at 40–60 Hz becomes uncomfortable at high pulse …

Neural networks are more than the sum of their parts, but the properties of those parts are
nonetheless important. For instance, neuronal properties affect the degree to which neurons …

Synaptic inhibition by GABA A receptors requires a transmembrane chloride gradient.
Hyperpolarization or shunting results from outward current produced by chloride flowing down this …

Correlated spiking has been widely observed, but its impact on neural coding remains
controversial. Correlation arising from comodulation of rates across neurons has been shown to …

10.7554/eLife.02370.001 Neuropathic pain remains notoriously difficult to treat despite
numerous drug targets. Here, we offer a novel explanation for this intractability. Computer …

Multiplexing refers to the simultaneous encoding of two or more signals. Neurons have been
shown to multiplex, but different stimuli require different multiplexing strategies. Whereas …

Pain, itch, heat, cold, and touch represent different percepts arising from somatosensory input.
How stimuli give rise to these percepts has been debated for over a century. Recent work …