Noroviruses are understudied because these important enteric pathogens have not been
cultured to date. We found that the norovirus murine norovirus 1 (MNV-1) infects macrophage-…

Noroviruses are a major cause of epidemic gastroenteritis in children and adults, and GII.4
has been the predominant genotype since its first documented occurrence in 1987. This study …

Host resistance to viral infection requires type I (α/β) and II (γ) interferon (IFN) production.
Another important defense mechanism is the degradative activity of macroautophagy (herein …

Noroviruses are global agents of acute gastroenteritis, but the development of control strategies
has been hampered by the absence of a robust animal model. Studies in chimpanzees …

In enteric viral infections, such as those with rotavirus and norovirus, individual viral particles
shed in stool are considered the optimal units of fecal-oral transmission. We reveal that …

Noroviruses are major pathogens associated with acute gastroenteritis worldwide. Their
RNA genomes are diverse, with two major genogroups (GI and GII) comprised of at least 28 …

Murine norovirus (MNV) is presently the only member of the genus Norovirus in the
Caliciviridae that can be propagated in cell culture. The goal of this study was to elucidate the …

Norwalk virus (NV) is a prototype strain of the genus Norovirus in the family Caliciviridae.
The human noroviruses have emerged as major agents of acute gastroenteritis in all age …

The MD145-12 strain (GII/4) is a member of the genus Norovirus in the Caliciviridae and
was detected in a patient with acute gastroenteritis in a Maryland nursing home. The open …

The third open reading frame (ORF3) located at the 3′ end of the genomic RNA of feline
calicivirus (FCV) encodes a small (12.2-kDa) minor structural protein of 106 amino acids …