User profiles for Stanley Brul

Stanley Brul

Professor of Molecular Biology and Microbial Food Safety
Verified email at uva.nl
Cited by 13001

Preservative agents in foods: mode of action and microbial resistance mechanisms

S Brul, P Coote - International journal of food microbiology, 1999 - Elsevier
Preservative agents are required to ensure that manufactured foods remain safe and
unspoiled. In this review, we will discuss the mode of action of both chemical and biological (nature-…

Dynamics of cell wall structure in Saccharomyces cerevisiae

…, P Mol, K Hellingwerf, S Brul - FEMS microbiology …, 2002 - academic.oup.com
The cell wall of Saccharomyces cerevisiae is an elastic structure that provides osmotic and
physical protection and determines the shape of the cell. The inner layer of the wall is largely …

In vivo measurement of cytosolic and mitochondrial pH using a pH-sensitive GFP derivative in Saccharomyces cerevisiae reveals a relation between intracellular pH …

R Orij, J Postmus, A Ter Beek, S Brul… - Microbiology, 2009 - microbiologyresearch.org
The specific pH values of cellular compartments affect virtually all biochemical processes,
including enzyme activity, protein folding and redox state. Accurate, sensitive and compartment…

Future challenges to microbial food safety

AH Havelaar, S Brul, A De Jong, R De Jonge… - International Journal of …, 2010 - Elsevier
Despite significant efforts by all parties involved, there is still a considerable burden of
foodborne illness, in which micro-organisms play a prominent role. Microbes can enter the food …

Cell wall perturbation in yeast results in dual phosphorylation of the Slt2/Mpk1 MAP kinase and in an Slt2-mediated increase in FKS2lacZ expression, glucanase …

…, C Ruiz, H Martin, W Morris, S Brul… - …, 2000 - microbiologyresearch.org
The protein kinase C (PKC1) pathway is essential for maintaining cell integrity in yeast.
Here it is shown that various forms of cell wall damage result in activation of the downstream …

Intracellular pH is a tightly controlled signal in yeast

R Orij, S Brul, GJ Smits - Biochimica et Biophysica Acta (BBA)-General …, 2011 - Elsevier
BACKGROUND: Nearly all processes in living cells are pH dependent, which is why intracellular
pH (pH i ) is a tightly regulated physiological parameter in all cellular systems. However…

Covalently linked cell wall proteins of Candida albicans and their role in fitness and virulence

…, GJ Sosinska, PWJ De Groot, S Brul - FEMS yeast …, 2009 - academic.oup.com
The cell wall of Candida albicans consists of an internal skeletal layer and an external
protein coat. This coat has a mosaic-like nature, containing c. 20 different protein species …

Transcriptional Response of Saccharomyces cerevisiae to the Plasma Membrane-Perturbing Compound Chitosan

A Zakrzewska, A Boorsma, S Brul, KJ Hellingwerf… - Eukaryotic …, 2005 - Am Soc Microbiol
Chitosan is a plasma membrane-perturbing compound consisting of linear chains of β-1,4-linked
glucosamine residues, which at acidic pHs become positively charged. It is extensively …

Assessment of heat resistance of bacterial spores from food product isolates by fluorescence monitoring of dipicolinic acid release

…, W Crielaard, KJ Hellingwerf, S Brul - Applied and …, 2005 - Am Soc Microbiol
This study is aimed at the development and application of a convenient and rapid optical assay
to monitor the wet-heat resistance of bacterial endospores occurring in food samples. We …

[HTML][HTML] Premature and accelerated aging: HIV or HAART?

RL Smith, R Boer, S Brul, Y Budovskaya… - Frontiers in genetics, 2013 - frontiersin.org
Highly active antiretroviral therapy (HAART) has significantly increased life expectancy of
the human immunodeficiency virus (HIV)-positive population. Nevertheless, the average …