We report that prospectively isolated, human CNS stem cells grown as neurospheres (hCNS-SCns)
survive, migrate, and express differentiation markers for neurons and …

CD8 + T cell responses are critical for anti-tumor immunity. While extensively profiled in the
tumor microenvironment, recent studies in mice identified responses in lymph nodes (LNs) …

BACKGROUND A previous phase I study showed that the infusion of autologous Tregs
expanded ex vivo into patients with recent-onset type 1 diabetes (T1D) had an excellent safety …

Direct isolation of human central nervous system stem cells (CNS‐SC) based on cell surface
markers yields a highly purified stem cell population that can extensively expand in vitro …

Infantile neuronal ceroid lipofuscinosis (INCL) is a fatal neurodegenerative disease caused
by a deficiency in the lysosomal enzyme palmitoyl protein thioesterase-1 (PPT1). Ppt1 …

Shiverer-immunodeficient (Shi-id) mice demonstrate defective myelination in the central
nervous system (CNS) and significant ataxia by 2 to 3 weeks of life. Expanded, banked human …

Three different cosmid clones were isolated from a genomic library of the tomato pathogen
Pseudomonas syringae pv. tomato, which, when introduced into the soybean pathogen P. …

Although heterogeneity is recognized within the murine satellite cell pool, a comprehensive
understanding of distinct subpopulations and their functional relevance in human satellite …

Naturally occurring cases of monogenic type 1 diabetes (T1D) help establish direct mechanisms
driving this complex autoimmune disease. A recently identified de novo germline gain-of…

Assessing individual responses to glucocorticoid drug therapies that compromise immune
status and affect survival outcomes in neuro-oncology is a great challenge. Here we introduce …