First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers

…, J Murphy, R Nielsen, M Dowler, JW Bennett, S Zarling… - Vaccine, 2013 - Elsevier
Background Immunization with genetically engineered, attenuated malaria parasites (GAP)
that arrest during liver infection confers sterile protection in mouse malaria models. A first …

[HTML][HTML] A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

…, V Dussupt, H Hack, R de la Barrera, S Zarling… - npj Vaccines, 2021 - nature.com
The emergence of SARS-CoV-2 variants of concern (VOC) requires adequate coverage of
vaccine protection. We evaluated whether a SARS-CoV-2 spike ferritin nanoparticle vaccine (…

Memory T cells maintain protracted protection against malaria

U Krzych, S Zarling, A Pichugin - Immunology letters, 2014 - Elsevier
Immunologic memory is one of the cardinal features of antigen-specific immune responses,
and the persistence of memory cells contributes to prophylactic immunizations against …

[HTML][HTML] Memory CD8 T Cells Specific for Plasmodia Liver-Stage Antigens Maintain Protracted Protection Against Malaria

U Krzych, S Dalai, S Zarling, A Pichugin - Frontiers in immunology, 2012 - frontiersin.org
Immunologic memory induced by pathogenic agents or vaccinations is inextricably linked to
long-lasting protection. Adequately maintained memory T and B cell pools assure a fast, …

The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria

S Zarling, D Berenzon, S Dalai, D Liepinsh… - The Journal of …, 2013 - journals.aai.org
Ag-specific memory T cell responses elicited by infections or vaccinations are inextricably
linked to long-lasting protective immunity. Studies of protective immunity among residents of …

[HTML][HTML] Identification of a Novel CD8 T Cell Epitope Derived from Plasmodium berghei Protective Liver-Stage Antigen

A Pichugin, S Zarling, L Perazzo, PE Duffy… - Frontiers in …, 2018 - frontiersin.org
We recently identified novel Plasmodium berghei (Pb) liver stage (LS) genes that as DNA
vaccines significantly reduce Pb LS parasite burden (LPB) in C57Bl/6 (B6) mice through a …

[HTML][HTML] Identification of novel pre-erythrocytic malaria antigen candidates for combination vaccines with circumsporozoite protein

…, R Morrison, Y Pei, L Juompan, N Milman, S Zarling… - PloS one, 2016 - journals.plos.org
Malaria vaccine development has been hampered by the limited availability of antigens
identified through conventional discovery approaches, and improvements are needed to …

TAP‐mediated processing of exoerythrocytic antigens is essential for protection induced with radiation‐attenuated Plasmodium sporozoites

…, N Steers, P De La Vega, S Zarling… - European journal of …, 2016 - Wiley Online Library
MHC class I dependent CD8 + T cells are essential for protection induced by radiation‐attenuated
Plasmodium sporozoites (RAS) in murine malaria models. Apart from the mechanism …

[HTML][HTML] A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B. 1.1. 7 and B. 1.351 virus variants in Syrian golden hamsters

…, V Dussupt, H Hack, R de la Barrera, S Zarling… - bioRxiv, 2021 - ncbi.nlm.nih.gov
The emergence of SARS-CoV-2 variants of concern (VOC) requires adequate coverage of
vaccine protection. We evaluated whether a spike ferritin nanoparticle vaccine (SpFN), …

Characterization of liver CD8 T cell subsets that are associated with protection against pre-erythrocytic Plasmodium parasites

S Zarling, U Krzych - Malaria Vaccines: Methods and Protocols, 2015 - Springer
Murine models of malaria, such as Plasmodium berghei (Pb) and Plasmodium yoelii (Py),
have been used for decades to identify correlates of protection associated with immunization …