The transport of amino acids in kidney and intestine is critical for the supply of amino acids to
all tissues and the homeostasis of plasma amino acid levels. This is illustrated by a number …

Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss
is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of …

The export of glutamine from astrocytes, and the uptake of glutamine by neurons, are integral
steps in the glutamate‐glutamine cycle, a major pathway for the replenishment of neuronal …

The emergence and spread of chloroquine-resistant Plasmodium falciparum malaria
parasites has been a disaster for world health. Resistance is conferred by mutations in the …

The transport of lactate is an essential part of the concept of metabolic coupling between
neurons and glia. Lactate transport in primary cultures of astroglial cells was shown to be …

Heterodimeric amino acid transporters are comprised of two subunits, a polytopic membrane
protein (light chain) and an associated type II membrane protein (heavy chain). The heavy …

Hartnup disorder (OMIM 234500) is an autosomal recessive abnormality of renal and
gastrointestinal neutral amino acid transport noted for its clinical variability. We localized a gene …

Glutamine release from astrocytes is an essential part of the glutamate–glutamine cycle in
the brain. Uptake of glutamine into cultured rat astrocytes occurs by at least four different …

Resorption of amino acids in kidney and intestine is mediated by transporters, which prefer
groups of amino acids with similar physico-chemical properties. It is generally assumed that …

The solute carrier 6 (SLC6) family of the human genome comprises transporters for
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play …