Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
…, C Langston, FL Graham, AL Beaudet, S Kochanek - Nature …, 1998 - nature.com
Many applications for human gene therapy would be facilitated by high levels and long duration
of physiologic gene expression. Adenoviral vectors are frequently used for gene transfer …
of physiologic gene expression. Adenoviral vectors are frequently used for gene transfer …
Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia
…, M Frye, T Thiele, S Kochanek… - Blood, The Journal …, 2021 - ashpublications.org
SARS-CoV-2 vaccine ChAdOx1 nCoV-19 (AstraZeneca) causes a thromboembolic
complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using …
complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using …
A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase.
S Kochanek, PR Clemens, K Mitani… - Proceedings of the …, 1996 - National Acad Sciences
Adenoviral vector-mediated gene transfer offers significant potential for gene therapy of
many human diseases. However, progress has been slowed by several limitations. First, the …
many human diseases. However, progress has been slowed by several limitations. First, the …
Adenoviral vectors for gene transfer and therapy
C Volpers, S Kochanek - The Journal of Gene Medicine: A cross …, 2004 - Wiley Online Library
Due to the very efficient nuclear entry mechanism of adenovirus and its low pathogenicity
for humans, adenovirus‐based vectors have become gene delivery vehicles that are widely …
for humans, adenovirus‐based vectors have become gene delivery vehicles that are widely …
Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons
…, FL Graham, S Kochanek… - Proceedings of the …, 1999 - National Acad Sciences
The efficiency of first-generation adenoviral vectors as gene delivery tools is often limited by
the short duration of transgene expression, which can be related to immune responses and …
the short duration of transgene expression, which can be related to immune responses and …
An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene
…, RJ Parks, FL Graham, S Kochanek… - Proceedings of the …, 1998 - National Acad Sciences
Adenoviral (Ad)-mediated in vivo gene transfer and expression are limited in part by cellular
immune responses to viral-encoded proteins and/or transgene immunogenicity. In an …
immune responses to viral-encoded proteins and/or transgene immunogenicity. In an …
Vaccine-induced COVID-19 mimicry syndrome
…, P Larghero, J Reis, S Bracharz, T Engler, S Kochanek… - Elife, 2022 - elifesciences.org
To fight the Covid-19 pandemic caused by the RNA virus SARS-CoV-2 a global vaccination
campaign is in progress to achieve the immunization of billions of people mainly with …
campaign is in progress to achieve the immunization of billions of people mainly with …
[HTML][HTML] Modification of adenovirus gene transfer vectors with synthetic polymers: a scientific review and technical guide
F Kreppel, S Kochanek - Molecular Therapy, 2008 - cell.com
The chemical modification of adenovirus (Ad) gene transfer vectors with synthetic polymers
is a promising strategy for overcoming typical in vivo hurdles associated with Ad-mediated …
is a promising strategy for overcoming typical in vivo hurdles associated with Ad-mediated …
Frequency and stability of chromosomal integration of adenovirus vectors
A Harui, S Suzuki, S Kochanek, K Mitani - Journal of virology, 1999 - Am Soc Microbiol
One of the limitations of adenovirus vectors is the lack of machinery necessary for their
integration into host chromosomes, resulting in short-term gene expression in dividing cells. We …
integration into host chromosomes, resulting in short-term gene expression in dividing cells. We …
Persistence in muscle of an adenoviral vector that lacks all viral genes
…, R Kelly, M Ontell, S Kochanek… - Proceedings of the …, 1997 - National Acad Sciences
Genetic correction of inherited muscle diseases, such as Duchenne muscular dystrophy, will
require long term expression of the recombinant protein following gene transfer. We have …
require long term expression of the recombinant protein following gene transfer. We have …