Infection-neutralizing antibody responses after severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection or coronavirus disease 2019 vaccination are an essential …

Eukaryotic cells have a layer of heterochromatin at the nuclear periphery. To investigate
mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in …

Psoriasis vulgaris is a common T cell–mediated inflammatory skin disease with a suspected
autoimmune pathogenesis. The human leukocyte antigen (HLA) class I allele, HLA-C*06:02…

The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the T H 17
subset of helper T cells remain unclear. Here we used a novel strategy for the conditional …

Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a high-risk subgroup of T-lineage
ALL characterized by specific stem cell and myeloid features. In adult ETP-ALL, no …

Since autumn 2020, rapid antigen tests (RATs) have been implemented in several countries
as an important pillar of the national testing strategy to rapidly screen for infections on site …

Mitochondrial fidelity is tightly linked to overall cellular homeostasis and is compromised in
ageing and various pathologies 1 , 2 – 3 . Mitochondrial malfunction needs to be relayed to …

During maternal-to-embryonic transition control of embryonic development gradually switches
from maternal RNAs and proteins stored in the oocyte to gene products generated after …

Background Deregulation of Wnt/β-catenin signaling is a hallmark of the majority of sporadic
forms of colorectal cancer and results in increased stability of the protein β-catenin. β-…

Cytogenetically normal acute myeloid leukemia (CN-AML) with biallelic CEBPA gene mutations
(biCEPBA) represents a distinct disease entity with a favorable clinical outcome. So far, …