In Alzheimer's disease, microglia cluster around β-amyloid deposits, suggesting that these
cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed …

Glioblastomas exhibit vast inter- and intra-tumoral heterogeneity, complicating the development
of effective therapeutic strategies. Current in vitro models are limited in preserving the …

Microglial cells closely interact with senile plaques in Alzheimer’s disease and acquire the
morphological appearance of an activated phenotype. The significance of this microglial …

The pathology of Alzheimer's disease has an inflammatory component that is characterized
by upregulation of proinflammatory cytokines, particularly in response to amyloid-β (Aβ). …

Molecular probes for selective identification of protein aggregates are important to advance
our understanding of the molecular pathogenesis underlying cerebral amyloidoses. Here we …

The Alzheimer disease-associated presenilin (PS) proteins apparently provide the active
site of γ-secretase, an unusual intramembrane-cleaving aspartyl protease. PSs principally …

The identification of microglia-associated, neurological disease-causing mutations in patients,
combined with studies in mouse models has highlighted microglia, the brain’s intrinsic …

The key pathological hallmarks—extracellular plaques and intracellular neurofibrillary
tangles (NFT)—described by Alois Alzheimer in his seminal 1907 article are still central to the …

Diets high in fat (HFD) are known to cause an immune response in the periphery as well as
the central nervous system. In peripheral adipose tissue, this immune response is primarily …

The γ-secretase complex catalyzes the final intramembraneous cleavage of the β-amyloid
precursor protein, liberating the neurotoxic amyloid β-peptide implicated in Alzheimer's …