Spatiotemporal gene expression programmes are orchestrated by transcriptional enhancers,
which are key regulatory DNA elements that engage in physical contacts with their target-…

The Polycomb repressive complexes PRC1 and PRC2 maintain embryonic stem cell (ESC)
pluripotency by silencing lineage-specifying developmental regulator genes 1 . Emerging …

Large-scale chromosome structure and spatial nuclear arrangement have been linked to
control of gene expression and DNA replication and repair. Genomic techniques based on …

Transcriptional control in large genomes often requires looping interactions between distal
DNA elements, such as enhancers and target promoters. Current chromosome conformation …

The discovery of interchromosomal interactions in higher eukaryotes points to a functional
interplay between genome architecture and gene expression, challenging the view of …

The mammalian genome harbors up to one million regulatory elements often located at
great distances from their target genes. Long-range elements control genes through physical …

Transcription in the eukaryotic nucleus has long been thought of as conforming to a model
in which RNA polymerase complexes are recruited to and track along isolated templates. …

Mammalian genomes are spatially organized into compartments, topologically associating
domains (TADs), and loops to facilitate gene regulation and other chromosomal functions. …

HiCUP is a pipeline for processing sequence data generated by Hi-C and Capture Hi-C (CHi-C)
experiments, which are techniques used to investigate three-dimensional genomic …

Capture Hi-C (CHi-C) is a method for profiling chromosomal interactions involving targeted
regions of interest, such as gene promoters, globally and at high resolution. Signal detection …