The kinase-activating mutation G2019S in leucine-rich repeat kinase 2 (LRRK2) is one of the
most common genetic causes of Parkinson’s disease (PD) and has spurred development …

The Aurora family of highly related serine/threonine kinases plays a key role in the regulation
of mitosis. Aurora1 and Aurora2 play important but distinct roles in the G 2 and M phases of …

Evaluation and optimization of drug metabolism and pharmacokinetic data plays an important
role in drug discovery and development and several reliable in vitro ADME models are …

Objective Divergent therapeutic outcomes on different disease domains have been noted
with IL-23 and IL-17A-blockade in PsA. Therefore, elucidating the role of RORγt, the master …

Purpose To assess the utility of Extended Clearance Classification System (ECCS) in
understanding absorption, distribution, metabolism, and elimination (ADME) attributes and …

Central-nervous-system, physiologically based pharmacokinetic (PBPK) models predict
exposure profiles in the brain, that is, the rate and extent of distribution. The current work …

Blocking chemokine receptor CC chemoattractant cytokine (chemokine) receptor (CCR) 6-dependent
T cell migration has therapeutic promise in inflammatory diseases. PF-07054894 …

Putative gain-of-function mutations in leucine-rich repeat kinase 2 (LRRK2), resulting in
increased kinase activity and cellular toxicity, are a leading genetic cause of Parkinson’s …

The c-Met proto-oncogene is a multifunctional receptor tyrosine kinase that is stimulated by
its ligand, hepatocyte growth factor (HGF), to induce cell growth, motility and morphogenesis. …

5647 The Aurora kinases, a family of highly related serine/threonine kinases are key regulators
of mitosis. Aurora1 and Aurora2 (also known as AuroraB and AuroraA, respectively) play …