Induction of chromosome instability by activation of yes-associated protein and forkhead box M1 in liver cancer

…, T Lutz, A Geldiyev, C Sticht, M Knaub, S Thomann… - Gastroenterology, 2017 - Elsevier
Background & Aims Many different types of cancer cells have chromosome instability. The
hippo pathway leads to phosphorylation of the transcriptional activator yes-associated protein …

[PDF][PDF] Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness

…, C Rupp, M Tóth, C Sticht, S Singer, S Thomann… - …, 2018 - Wiley Online Library
The loss of epithelial cell polarity plays an important role in the development and progression
of liver cancer. However, the specific molecular mechanisms supporting tumor initiation …

YAP-dependent induction of UHMK1 supports nuclear enrichment of the oncogene MYBL2 and proliferation in liver cancer cells

T Wei, SME Weiler, M Tóth, C Sticht, T Lutz, S Thomann… - Oncogene, 2019 - nature.com
The oncogene yes-associated protein (YAP) is a key modifier of liver homeostasis and
regulates mitosis in hepatocytes as well as in malignantly transformed cells. However, the …

YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis

S Thomann, SME Weiler, S Marquard, F Rose, CR Ball… - Cancer Research, 2020 - AACR
YAP-dependent changes of the liver vascular niche comprise the formation of heterologous
communication hubs in which tumor cell-derived factors modify the cross-talk between EC …

[HTML][HTML] Measurement and evaluation of gaseous and particulate emissions from burning scented and unscented candles

…, J Gu, S Wientzek, R Harrington, S Thomann - Environment …, 2021 - Elsevier
It has been known for a long time that incomplete combustion processes produce by-products
that are harmful to human health. Particularly high concentrations of such by-products can …

[HTML][HTML] Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in …

S Marquard, S Thomann, SME Weiler… - Cell Communication and …, 2020 - Springer
Background Overexpression and nuclear enrichment of the oncogene yes-associated
protein (YAP) cause tumor initiation and support tumor progression in human hepatocellular …

YAP‐induced Ccl2 expression is associated with a switch in hepatic macrophage identity and vascular remodelling in liver cancer

S Thomann, SME Weiler, T Wei, C Sticht… - Liver …, 2021 - Wiley Online Library
Background & aim The development of hepatocellular carcinoma (HCC) is associated with
the formation of communication networks leading to the recruitment of disease‐modifying …

Three‐dimensional reconstruction of prostate cancer architecture with serial immunohistochemical sections: hallmarks of tumour growth, tumour compartmentalisation …

Y Tolkach, S Thomann, G Kristiansen - Histopathology, 2018 - Wiley Online Library
Aims Conventional morphology of prostate cancer considers only the two‐dimensional (2D)
architecture of the tumour. Our aim was to examine the feasibility of three‐dimensional (3D) …

[HTML][HTML] Selective targeting of liver cancer with the endothelial marker CD146

S Thomann, T Longerich, AV Bazhin, W Mier… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Hepatocellular carcinomas are well-vascularized tumors; the endothelial cells in these
tumors have a specific phenotype. Our aim was to develop a new approach for tumor-specific …

[HTML][HTML] Immunologic landscape of human hepatic hemangiomas and epithelioid hemangioendotheliomas

S Thomann, T Metzler, M Tóth… - Hepatology …, 2024 - journals.lww.com
… , Thomas Metzler, Marcell Tóth, and Carolin Mogler: acquisition and analysis of data;
Stefan Thomann and Carolin Mogler: drafting the manuscript and the figures; and Peter …