Alzheimer's disease (AD) is characterized by memory loss, cognitive decline, and
devastating neurodegeneration, not only as a result of the extracellular accumulation of beta-amyloid …

Mouse models of human diseases are invaluable tools for studying pathogenic mechanisms
and testing interventions and therapeutics. For disorders such as Alzheimer’s disease in …

Allosteric modulation of G-protein–coupled receptors represents a key goal of current
pharmacology. In particular, endogenous allosteric modulators might represent important targets of …

Animal models of disease are valuable resources for investigating pathogenic mechanisms
and potential therapeutic interventions. However, for complex disorders such as Alzheimer’s …

The majority of Alzheimer’s disease (AD) cases are late-onset and occur sporadically, however
most mouse models of the disease harbor pathogenic mutations, rendering them better …

Background Spinal cord injury (SCI) is a severe neurological disorder with many disabling
consequences, including persistent neuropathic pain, which develops in about 40 % of SCI …

Astrocytes are key cells for adequate brain formation and regulation of cerebral blood flow
as well as for the maintenance of neuronal metabolism, neurotransmitter synthesis and …

Alzheimer's disease (AD) is a major cause of dementia, disability, and death in the elderly.
Despite recent advances in our understanding of the basic biological mechanisms underlying …

Alternative splicing is widely acknowledged to be a crucial regulator of gene expression and
is a key contributor to both normal developmental processes and disease states. While cost-…

Degenerative cervical myelopathy (DCM) is the most common progressive nontraumatic
spinal cord injury. The most common recommended treatment is surgical decompression, …