User profiles for Stefania Nicoli

Stefania Nicoli, Ph.D.

Internal Medicine, Yale University
Verified email at yale.edu
Cited by 3505

MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis

…, J Zhang, M Gu, M Gerstein, M Schwartz, S Nicoli - Nature cell …, 2019 - nature.com
Vertebrate tissues exhibit mechanical homeostasis, showing stable stiffness and tension over
time and recovery after changes in mechanical stress. However, the regulatory pathways …

MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis

S Nicoli, C Standley, P Walker, A Hurlstone, KE Fogarty… - Nature, 2010 - nature.com
Within the circulatory system, blood flow regulates vascular remodelling 1 , stimulates blood
stem cell formation 2 , and has a role in the pathology of vascular disease 3 . During …

Role of miRNAs and epigenetics in neural stem cell fate determination

MA Lopez-Ramirez, S Nicoli - Epigenetics, 2014 - Taylor & Francis
The regulation of gene expression that determines stem cell fate determination is tightly
controlled by both epigenetic and posttranscriptional mechanisms. Indeed, small non-coding …

miRNAs in endothelial cell signaling: the endomiRNAs

MM Santoro, S Nicoli - Experimental cell research, 2013 - Elsevier
microRNAs (miRNAs) have a pivotal role during the formation and function of the cardiovascular
system. More than 300 miRNAs have been currently found within the mammalian …

Mammalian tumor xenografts induce neovascularization in zebrafish embryos

S Nicoli, D Ribatti, F Cotelli, M Presta - Cancer research, 2007 - AACR
The zebrafish (Danio rerio)/tumor xenograft model represents a powerful new model system
in cancer. Here, we describe a novel exploitation of the zebrafish model to investigate tumor …

The zebrafish/tumor xenograft angiogenesis assay

S Nicoli, M Presta - Nature protocols, 2007 - nature.com
Here we describe a method to study tumor angiogenesis in zebrafish (Danio rerio) based
on the injection of proangiogenic mammalian tumor cells into the perivitelline space of …

Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point

N Baeyens, S Nicoli, BG Coon, TD Ross… - elife, 2015 - elifesciences.org
10.7554/eLife.04645.001 Vascular remodeling under conditions of growth or exercise, or
during recovery from arterial restriction or blockage is essential for health, but mechanisms are …

[PDF][PDF] miR-221 is required for endothelial tip cell behaviors during vascular development

S Nicoli, CP Knyphausen, LJ Zhu, A Lakshmanan… - Developmental cell, 2012 - cell.com
Angiogenesis requires coordination of distinct cell behaviors between tip and stalk cells.
Although this process is governed by regulatory interactions between the vascular endothelial …

Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor

H Stabile, S Mitola, E Moroni, M Belleri, S Nicoli… - Blood, 2007 - ashpublications.org
Angiogenesis plays a key role in various physiologic and pathologic conditions, including
tumor growth. Drm/gremlin, a member the Dan family of bone morphogenic protein (BMP) …

Fibroblast growth factor receptor-1 is essential for in vitro cardiomyocyte development

P Dell'Era, R Ronca, L Coco, S Nicoli, M Metra… - Circulation …, 2003 - Am Heart Assoc
Fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling plays a crucial role in mesoderm
formation and patterning. Heartless mutant studies in Drosophila suggest that FGFR1, …